DOT1L a protein-lysine N-methyltransferase of the seven beta-strand class. Catalyzes the mono-, di- and tri-methylation of H3K79. Methylated H3K79 is associated with active gene transcription. DOT1L activity drives proliferation of mixed lineage leukemia 1 protein (MLL)-rearranged leukemias, inducing the aberrant transcription of a number of leukemogenic genes including HOXA9 and MEIS1. Binds to DNA. Belongs to the class I-like SAM-binding methyltransferase superfamily. DOT1 family. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Amino Acid Metabolism - lysine degradation; EC; Methyltransferase; Methyltransferase, protein lysine
Chromosomal Location of Human Ortholog: 10|10 C1
Cellular Component:  intracellular membrane-bounded organelle; nucleoplasm; nucleus; protein-containing complex
Molecular Function:  histone methyltransferase activity; histone methyltransferase activity (H3-K79 specific); histone-lysine N-methyltransferase activity; transcription factor binding
Biological Process:  chromatin silencing at telomere; DNA damage checkpoint; histone H3-K79 methylation; positive regulation of cell proliferation; positive regulation of transcription by RNA polymerase II; regulation of JAK-STAT cascade; regulation of transcription regulatory region DNA binding
Reference #:  Q571B8 (UniProtKB)
Alt. Names/Synonyms: A630076O07; AW907654; Dot1; DOT1-like, histone H3 methyltransferase; DOT1-like, histone H3 methyltransferase (S. cerevisiae); Dot1l; histone H3 methyltransferase DOT1; histone methyltransferase DOT1L; Histone-lysine N-methyltransferase, H3 lysine-79 specific; KMT4; mDot1; mKIAA1814; MKIAA1814 protein; OTTMUSP00000018849
Gene Symbols: Dot1l
Molecular weight: 165,081 Da
Basal Isoelectric point: 9.6  Predict pI for various phosphorylation states
CST Pathways:  Histone Methylation
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  BioGPS  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene