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DOCK1
Involved in cytoskeletal rearrangements required for phagocytosis of apoptotic cells and cell motility. Along with DOCK1, mediates CRK/CRKL regulation of epithelial and endothelial cell spreading and migration on type IV collagen. Functions as a guanine nucleotide exchange factor (GEF), which activates Rac Rho small GTPases by exchanging bound GDP for free GTP. Its GEF activity may be enhanced by ELMO1. Belongs to the DOCK family. Highly expressed in placenta, lung, kidney, pancreas and ovary. Expressed at intermediate level in thymus, testes and colon. Note: This description may include information from UniProtKB.
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| Protein type: Adaptor/scaffold; Cytoskeletal; GEF; GEF, Rac/Rho; Motility/polarity/chemotaxis |
| Chromosomal Location of mouse Ortholog: 7|7 F3 |
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Cellular Component:
cytoplasm; cytosol; guanyl-nucleotide exchange factor complex; membrane; nuclear speck; nucleoplasm; plasma membrane
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Molecular Function:
guanyl-nucleotide exchange factor activity; protein binding; SH3 domain binding; small GTPase binding
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Biological Process:
apoptotic process; cell migration; hematopoietic progenitor cell differentiation; myoblast fusion; phagocytosis; positive regulation of epithelial cell migration; positive regulation of substrate adhesion-dependent cell spreading; small GTPase mediated signal transduction
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Reference #:
Q8BUR4
(UniProtKB)
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Alt. Names/Synonyms: 180 kDa protein downstream of CRK; 9130006G06Rik; AI854900; b2b3190C; b2b3190Clo; D630004B07Rik; dedicator of cyto-kinesis 1; dedicator of cytokinesis 1; Dedicator of cytokinesis protein 1; Dock1; Dock18; DOCK180
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Gene Symbols: Dock1
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Molecular weight:
215,085 Da
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Basal Isoelectric point:
7.41
Predict pI for various phosphorylation states
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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