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DERL2
Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal glycoproteins, but not that of misfolded nonglycoproteins. May act by forming a channel that allows the retrotranslocation of misfolded glycoproteins into the cytosol where they are ubiquitinated and degraded by the proteasome. May mediate the interaction between VCP and misfolded glycoproteins. May also be involved in endoplasmic reticulum stress-induced pre-emptive quality control, a mechanism that selectively attenuates the translocation of newly synthesized proteins into the endoplasmic reticulum and reroutes them to the cytosol for proteasomal degradation. (Microbial infection) In contrast to DERL1, it is not involved in the degradation of MHC class I heavy chains following infection by cytomegaloviruses. Belongs to the derlin family. Ubiquitous. Overexpressed in various hepatocarcinomas. Note: This description may include information from UniProtKB.
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| Protein type: Endoplasmic reticulum; Membrane protein, integral; Membrane protein, multi-pass |
| Chromosomal Location of mouse Ortholog: 11 B4|11 43.21 cM |
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Cellular Component:
early endosome; endoplasmic reticulum; endoplasmic reticulum membrane; Hrd1p ubiquitin ligase ERAD-L complex; late endosome; membrane
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Molecular Function:
misfolded protein binding; protein binding; protein-containing complex binding; signal recognition particle binding; ubiquitin-specific protease binding
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Biological Process:
endoplasmic reticulum unfolded protein response; negative regulation of retrograde protein transport, ER to cytosol; positive regulation of cell growth; positive regulation of cell population proliferation; response to unfolded protein; retrograde protein transport, ER to cytosol; suckling behavior; ubiquitin-dependent ERAD pathway
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Reference #:
Q8BNI4
(UniProtKB)
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Alt. Names/Synonyms: BC005682; carcinoma related; CGI-10; CGI-101; Degradation in endoplasmic reticulum protein 2; Der1-like domain family, member 2; Der1-like protein 2; Der2; Derl; Derl2; derlin 2; Derlin-2; F-LANa; Flana; MGC11613; OTTMUSP00000006360; RP23-83I13.8
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Gene Symbols: Derl2
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Molecular weight:
27,640 Da
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Basal Isoelectric point:
6.73
Predict pI for various phosphorylation states
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