DERL2 Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal glycoproteins, but not that of misfolded nonglycoproteins. May act by forming a channel that allows the retrotranslocation of misfolded glycoproteins into the cytosol where they are ubiquitinated and degraded by the proteasome. May mediate the interaction between VCP and the degradation substrate. In contrast to DERL1, it is not involved in the degradation of MHC class I heavy chains following infection by cytomegaloviruses. May play a role in cell proliferation. Belongs to the derlin family. Note: This description may include information from UniProtKB.
Protein type: Endoplasmic reticulum; Membrane protein, integral; Membrane protein, multi-pass
Chromosomal Location of Human Ortholog: 11 B4|11 43.21 cM
Cellular Component:  early endosome; endoplasmic reticulum; integral component of endoplasmic reticulum membrane; integral component of membrane; late endosome; membrane
Biological Process:  endoplasmic reticulum unfolded protein response; negative regulation of retrograde protein transport, ER to cytosol; positive regulation of cell growth; positive regulation of cell proliferation; response to unfolded protein; retrograde protein transport, ER to cytosol; suckling behavior; ubiquitin-dependent ERAD pathway
Reference #:  Q8BNI4 (UniProtKB)
Alt. Names/Synonyms: BC005682; carcinoma related; CGI-101; Degradation in endoplasmic reticulum protein 2; Der1-like domain family, member 2; Der1-like protein 2; Der2; Derl2; derlin 2; Derlin-2; F-LANa; Flana; MGC11613; OTTMUSP00000006360; RP23-83I13.8
Gene Symbols: Derl2
Molecular weight: 27,640 Da
Basal Isoelectric point: 6.73  Predict pI for various phosphorylation states
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DERL2

Protein Structure Not Found.

Cross-references to other databases:  STRING  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene