STAT5B transcription factor of the STAT family. Phosphorylated and activated by receptor-associated kinases triggered by cytokines including IL2, IL3, GM-CSF, and various growth hormones. It has been shown to be involved in diverse biological processes, such as TCR signaling, apoptosis, adult mammary gland development, and sexual dimorphism of liver gene expression. Forms homo- or heterodimers that translocate into the nucleus where they regulate transcription. Note: This description may include information from UniProtKB.
Protein type: DNA-binding; Oncoprotein; Transcription factor
Chromosomal Location of Human Ortholog: 17q21.2
Cellular Component:  cytoplasm; cytosol; nucleoplasm; nucleus
Molecular Function:  chromatin binding; DNA-binding transcription activator activity, RNA polymerase II-specific; DNA-binding transcription factor activity; DNA-binding transcription factor activity, RNA polymerase II-specific; glucocorticoid receptor binding; protein binding; protein dimerization activity; RNA polymerase II proximal promoter sequence-specific DNA binding
Biological Process:  cellular response to epidermal growth factor stimulus; cellular response to growth factor stimulus; cellular response to hormone stimulus; cytokine-mediated signaling pathway; development of secondary female sexual characteristics; development of secondary male sexual characteristics; female pregnancy; interleukin-15-mediated signaling pathway; interleukin-2-mediated signaling pathway; interleukin-7-mediated signaling pathway; interleukin-9-mediated signaling pathway; JAK-STAT cascade; JAK-STAT cascade involved in growth hormone signaling pathway; lactation; lipid storage; luteinization; mast cell migration; natural killer cell differentiation; negative regulation of apoptotic process; negative regulation of erythrocyte differentiation; Peyer's patch development; positive regulation of activated T cell proliferation; positive regulation of B cell differentiation; positive regulation of erythrocyte differentiation; positive regulation of gamma-delta T cell differentiation; positive regulation of inflammatory response; positive regulation of interleukin-2 biosynthetic process; positive regulation of mitotic cell cycle; positive regulation of multicellular organism growth; positive regulation of natural killer cell differentiation; positive regulation of natural killer cell mediated cytotoxicity; positive regulation of natural killer cell proliferation; positive regulation of transcription by RNA polymerase II; progesterone metabolic process; regulation of epithelial cell differentiation; regulation of multicellular organism growth; regulation of steroid metabolic process; regulation of transcription by RNA polymerase II; response to estradiol; response to interleukin-4; T cell differentiation in thymus; T cell homeostasis; taurine metabolic process
Disease: Growth Hormone Insensitivity With Immunodeficiency
Reference #:  P51692 (UniProtKB)
Alt. Names/Synonyms: Signal transducer and activator of transcription 5B; STA5B; STAT5; STAT5B; transcription factor STAT5B
Gene Symbols: STAT5B
Molecular weight: 89,866 Da
Basal Isoelectric point: 5.71  Predict pI for various phosphorylation states
CST Pathways:  ErbB/HER Signaling  |  IL6 Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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STAT5B

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene