CPSF2 Component of the cleavage and polyadenylation specificity factor (CPSF) complex that play a key role in pre-mRNA 3'-end formation, recognizing the AAUAAA signal sequence and interacting with poly(A) polymerase and other factors to bring about cleavage and poly(A) addition. Involved in the histone 3' end pre-mRNA processing. Belongs to the metallo-beta-lactamase superfamily. RNA-metabolizing metallo-beta-lactamase-like family. CPSF2/YSH1 subfamily. Note: This description may include information from UniProtKB.
Protein type: RNA splicing
Chromosomal Location of Human Ortholog: 12|12 E
Cellular Component:  mRNA cleavage and polyadenylation specificity factor complex; nucleus
Molecular Function:  RNA binding
Biological Process:  mRNA 3'-end processing by stem-loop binding and cleavage; mRNA cleavage; mRNA polyadenylation; mRNA processing
Reference #:  O35218 (UniProtKB)
Alt. Names/Synonyms: 100kDa; 2610024B04Rik; AI662483; cleavage and polyadenylation specific factor 2; cleavage and polyadenylation specific factor 2, 100kD subunit; Cleavage and polyadenylation specificity factor 100 kDa subunit; Cleavage and polyadenylation specificity factor subunit 2; Cpsf; CPSF 100 kDa subunit; Cpsf100; Cpsf2; Mcpsf; mKIAA1367
Gene Symbols: Cpsf2
Molecular weight: 88,383 Da
Basal Isoelectric point: 4.98  Predict pI for various phosphorylation states
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CPSF2

Protein Structure Not Found.

Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene