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CPSF2
Component of the cleavage and polyadenylation specificity factor (CPSF) complex that play a key role in pre-mRNA 3'-end formation, recognizing the AAUAAA signal sequence and interacting with poly(A) polymerase and other factors to bring about cleavage and poly(A) addition. Involved in the histone 3' end pre-mRNA processing. Belongs to the metallo-beta-lactamase superfamily. RNA-metabolizing metallo-beta-lactamase-like family. CPSF2/YSH1 subfamily. Note: This description may include information from UniProtKB.
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| Protein type: RNA splicing |
| Chromosomal Location of mouse Ortholog: 12|12 E |
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Cellular Component:
glutamatergic synapse; mRNA cleavage and polyadenylation specificity factor complex; nucleus; postsynapse
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Molecular Function:
RNA binding
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Biological Process:
mRNA 3'-end processing by stem-loop binding and cleavage; mRNA polyadenylation; mRNA processing
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Reference #:
O35218
(UniProtKB)
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Alt. Names/Synonyms: 100kD; 100kDa; 2610024B04Rik; AI662483; cleavage and polyadenylation specific factor 2; cleavage and polyadenylation specific factor 2, 100kD subunit; Cleavage and polyadenylation specificity factor 100 kDa subunit; Cleavage and polyadenylation specificity factor subunit 2; Cpsf; CPSF 100 kDa subunit; Cpsf100; Cpsf2; Mcpsf; mKIAA1367
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Gene Symbols: Cpsf2
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Molecular weight:
88,383 Da
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Basal Isoelectric point:
4.98
Predict pI for various phosphorylation states
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