CLN3 Involved in microtubule-dependent, anterograde transport of late endosomes and lysosomes. Belongs to the battenin family. 7 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Apoptosis; Autophagy; Chaperone; Membrane protein, integral; Membrane protein, multi-pass; Mitochondrial; Vesicle
Chromosomal Location of mouse Ortholog: 7 F3|7 69.16 cM
Cellular Component:  autolysosome; autophagosome; caveola; cytoplasm; cytoplasmic vesicle; early endosome; early endosome membrane; endoplasmic reticulum; endosome; Golgi apparatus; Golgi membrane; Golgi stack; late endosome; lysosomal membrane; lysosome; membrane; membrane raft; neuron projection; nucleus; plasma membrane; recycling endosome; synapse; synaptic vesicle; trans-Golgi network; vacuole
Molecular Function:  calcium-dependent protein binding; glycolipid binding; protein binding; sulfatide binding
Biological Process:  actin cytoskeleton organization; action potential; amino acid transport; amyloid precursor protein catabolic process; associative learning; autophagosome maturation; autophagosome-lysosome fusion; blood vessel endothelial cell migration; cellular water homeostasis; endocytosis; establishment of localization in cell; glycerophospholipid biosynthetic process; glycolipid transport; Golgi to lysosome transport; ionotropic glutamate receptor signaling pathway; L-arginine transmembrane transport; learning or memory; lysosomal lumen acidification; lysosomal lumen pH elevation; lysosomal protein catabolic process; lysosome organization; macroautophagy; membrane organization; negative regulation of apoptotic process; negative regulation of catalytic activity; negative regulation of neuron apoptotic process; negative regulation of proteolysis; neuromuscular process controlling balance; neurotransmitter metabolic process; phagosome-lysosome docking; phagosome-lysosome fusion; plasma membrane raft organization; positive regulation of caveolin-mediated endocytosis; positive regulation of Golgi to plasma membrane protein transport; positive regulation of pinocytosis; positive regulation of protein phosphorylation; protein localization to membrane; protein localization to plasma membrane; protein phosphorylation; protein processing; receptor-mediated endocytosis; regulation of arginine biosynthetic process; regulation of autophagosome maturation; regulation of autophagosome size; regulation of autophagy; regulation of cellular response to osmotic stress; regulation of cytoskeleton organization; regulation of cytosolic calcium ion concentration; regulation of fibroblast migration; regulation of filopodium assembly; regulation of gene expression; regulation of intracellular pH; regulation of modification of synaptic structure; regulation of phagosome maturation; regulation of protein localization to plasma membrane; regulation of protein processing; regulation of short-term neuronal synaptic plasticity; regulation of synaptic transmission, GABAergic; regulation of synaptic transmission, glutamatergic; renal potassium excretion; vesicle transport along microtubule
Reference #:  Q61124 (UniProtKB)
Alt. Names/Synonyms: AI323623; batt; Battenin; ceroid lipofuscinosis, neuronal 3, juvenile (Batten, Spielmeyer-Vogt disease); Cln3; OTTMUSP00000021442; OTTMUSP00000021443; Protein CLN3
Gene Symbols: Cln3
Molecular weight: 47,657 Da
Basal Isoelectric point: 5.25  Predict pI for various phosphorylation states
Select Structure to View Below

CLN3

Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene