|
CLASP1
Microtubule plus-end tracking protein that promotes the stabilization of dynamic microtubules. Involved in the nucleation of noncentrosomal microtubules originating from the trans-Golgi network (TGN). Required for the polarization of the cytoplasmic microtubule arrays in migrating cells towards the leading edge of the cell. May act at the cell cortex to enhance the frequency of rescue of depolymerizing microtubules by attaching their plus-ends to cortical platforms composed of ERC1 and PHLDB2. This cortical microtubule stabilizing activity is regulated at least in part by phosphatidylinositol 3-kinase signaling. Also performs a similar stabilizing function at the kinetochore which is essential for the bipolar alignment of chromosomes on the mitotic spindle. Belongs to the CLASP family. 5 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
|
| Protein type: Cell cycle regulation; Motility/polarity/chemotaxis |
| Chromosomal Location of mouse Ortholog: 1|1 E2.3 |
|
Cellular Component:
basal cortex; cell cortex; centrosomal corona; centrosome; chromosome; chromosome, centromeric region; cortical microtubule cytoskeleton; cytoplasm; cytoplasmic microtubule; cytoskeleton; focal adhesion; Golgi apparatus; kinetochore; microtubule; microtubule cytoskeleton; microtubule organizing center; mitotic spindle; spindle microtubule
|
|
Molecular Function:
dystroglycan binding; kinetochore binding; microtubule binding; microtubule plus-end binding; protein binding
|
|
Biological Process:
astral microtubule organization; cell cycle; cell division; cell migration; establishment of cell polarity; establishment of mitotic spindle localization; establishment of spindle orientation; exit from mitosis; Golgi organization; microtubule anchoring; microtubule bundle formation; microtubule cytoskeleton organization; microtubule nucleation; microtubule organizing center organization; mitotic spindle assembly; mitotic spindle organization; negative regulation of microtubule depolymerization; negative regulation of microtubule polymerization or depolymerization; negative regulation of stress fiber assembly; negative regulation of wound healing, spreading of epidermal cells; positive regulation of basement membrane assembly involved in embryonic body morphogenesis; positive regulation of epithelial cell migration; positive regulation of exocytosis; positive regulation of extracellular matrix disassembly; regulation of epithelial to mesenchymal transition; regulation of focal adhesion assembly; regulation of gastrulation; regulation of microtubule cytoskeleton organization; vesicle targeting
|
|
Reference #:
Q80TV8
(UniProtKB)
|
|
Alt. Names/Synonyms: 1700030C23Rik; 5730583A19Rik; B130045P17Rik; CLA; CLAP1; Clasp1; CLASP1alpha; CLIP associating protein 1; CLIP-associating protein 1; CLIP-associating protein CLASP1; Cytoplasmic linker-associated protein 1; Kiaa0622; mCL; mKIAA0622
|
|
Gene Symbols: Clasp1
|
|
Molecular weight:
169,227 Da
|
|
Basal Isoelectric point:
9.15
Predict pI for various phosphorylation states
|
