|
CDO1
Initiates several important metabolic pathways related to pyruvate and several sulfurate compounds including sulfate, hypotaurine and taurine. Critical regulator of cellular cysteine concentrations. Has an important role in maintaining the hepatic concentation of intracellular free cysteine within a proper narrow range. Belongs to the cysteine dioxygenase family. Highly expressed in liver and placenta. Low expression in heart, brain and pancreas. Also detected in hepatoblastoma Hep-G2 cells. Note: This description may include information from UniProtKB.
|
| Protein type: Amino Acid Metabolism - cysteine and methionine; EC 1.13.11.20; Other Amino Acids Metabolism - taurine and hypotaurine; Oxidoreductase |
| Chromosomal Location of mouse Ortholog: 18 C|18 24.75 cM |
|
Cellular Component:
cytosol; plasma membrane
|
|
Molecular Function:
cysteine dioxygenase activity; dioxygenase activity; ferrous iron binding; iron ion binding; metal ion binding; nickel cation binding; oxidoreductase activity; oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen; zinc ion binding
|
|
Biological Process:
L-cysteine catabolic process; L-cysteine catabolic process to taurine; lactation; response to amino acid; response to cAMP; response to ethanol; response to glucagon; response to glucocorticoid; response to organonitrogen compound; taurine metabolic process
|
|
Reference #:
P60334
(UniProtKB)
|
|
Alt. Names/Synonyms: 1300002L19Rik; CDO; CDO-I; Cdo1; cysteine dioxygenase 1, cytosolic; Cysteine dioxygenase type 1; Cysteine dioxygenase type I; cytosolic cysteine dioxygenase 1; D18Ucl; D18Ucla3
|
|
Gene Symbols: Cdo1
|
|
Molecular weight:
23,026 Da
|
|
Basal Isoelectric point:
5.98
Predict pI for various phosphorylation states
|
