CDO1 Initiates several important metabolic pathways related to pyruvate and several sulfurate compounds including sulfate, hypotaurine and taurine. Critical regulator of cellular cysteine concentrations. Has an important role in maintaining the hepatic concentation of intracellular free cysteine within a proper narrow range. Belongs to the cysteine dioxygenase family. Highly expressed in liver and placenta. Low expression in heart, brain and pancreas. Also detected in hepatoblastoma Hep-G2 cells. Note: This description may include information from UniProtKB.
Protein type: Amino Acid Metabolism - cysteine and methionine; EC 1.13.11.20; Other Amino Acids Metabolism - taurine and hypotaurine; Oxidoreductase
Chromosomal Location of Human Ortholog: 18 C|18 24.75 cM
Cellular Component:  cytosol
Molecular Function:  cysteine dioxygenase activity; dioxygenase activity; ferrous iron binding; iron ion binding; metal ion binding; oxidoreductase activity; oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
Biological Process:  L-cysteine catabolic process; L-cysteine catabolic process to taurine; lactation; oxidation-reduction process; response to amino acid; response to cAMP; response to ethanol; response to glucagon; response to glucocorticoid; response to organonitrogen compound; taurine metabolic process
Reference #:  P60334 (UniProtKB)
Alt. Names/Synonyms: 1300002L19Rik; CDO; CDO-I; Cdo1; cysteine dioxygenase 1, cytosolic; Cysteine dioxygenase type 1; Cysteine dioxygenase type I; cytosolic cysteine dioxygenase 1; D18Ucl; D18Ucla3
Gene Symbols: Cdo1
Molecular weight: 23,026 Da
Basal Isoelectric point: 5.98  Predict pI for various phosphorylation states
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CDO1

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  RCSB PDB  |  ENZYME  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene