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CDK20
Required for high-level Shh responses in the developing neural tube. Together with TBC1D32, controls the structure of the primary cilium by coordinating assembly of the ciliary membrane and axoneme, allowing GLI2 to be properly activated in response to SHH signaling. Involved in cell growth. Activates CDK2, a kinase involved in the control of the cell cycle, by phosphorylating residue 'Thr-160'. Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily. 5 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: CCRK subfamily; CDK family; CDK/CCRK subfamily; CMGC group; Cell cycle regulation; EC 2.7.11.22; Kinase, protein; Motility/polarity/chemotaxis; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor) |
| Chromosomal Location of mouse Ortholog: 13|13 B3 |
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Cellular Component:
cell projection; cilium; cytoplasm; nucleoplasm; nucleus
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Molecular Function:
ATP binding; kinase activity; nucleotide binding; protein binding; protein kinase activity; protein serine/threonine kinase activity; transferase activity
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Biological Process:
cell cycle; cell division; embryonic brain development; embryonic camera-type eye development; embryonic skeletal system development; floor plate formation; multicellular organism development; negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning; neural tube closure; phosphorylation; protein localization to cilium; protein phosphorylation; regulation of protein maturation; regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning; roof of mouth development
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Reference #:
Q9JHU3
(UniProtKB)
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Alt. Names/Synonyms: 4932702G04Rik; AU019450; AW558027; CAK-kinase p42; Ccr; Ccrk; Cdch; CDK-activating kinase p42; CDK-related protein kinase PNQLARE; Cdk20; cell cycle related kinase; Cell cycle-related kinase; Cell division protein kinase 20; Cyclin-dependent kinase 20; Cyclin-dependent protein kinase H; Cyclin-kinase-activating kinase p42; MGC38901; p42; PNQLARE
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Gene Symbols: Cdk20
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Molecular weight:
38,379 Da
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Basal Isoelectric point:
6.11
Predict pI for various phosphorylation states
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