BTLA Inhibitory receptor on lymphocytes that negatively regulates antigen receptor signaling via PTPN6/SHP-1 and PTPN11/SHP-2. May interact in cis (on the same cell) or in trans (on other cells) with TNFRSF14. In cis interactions, appears to play an immune regulatory role inhibiting in trans interactions in naive T cells to maintain a resting state. In trans interactions, can predominate during adaptive immune response to provide survival signals to effector T cells. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral
Chromosomal Location of mouse Ortholog: 16|16 B5
Cellular Component:  external side of plasma membrane; membrane; plasma membrane
Molecular Function:  protein binding; signaling receptor activity
Biological Process:  adaptive immune response; cell surface receptor signaling pathway; immune response-regulating cell surface receptor signaling pathway; immune system process; negative regulation of alpha-beta T cell proliferation; negative regulation of B cell proliferation; negative regulation of T cell proliferation
Reference #:  Q7TSA3 (UniProtKB)
Alt. Names/Synonyms: A630002H24; B and T lymphocyte associated; B and T lymphocyte attenuator; B- and T-lymphocyte attenuator; B- and T-lymphocyte-associated protein; Btla; CD272; MGC124217; MGC124218; OTTMUSP00000015921
Gene Symbols: Btla
Molecular weight: 34,337 Da
Basal Isoelectric point: 7.11  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  Reactome  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene