AUP1 May play a role in the translocation of terminally misfolded proteins from the endoplasmic reticulum lumen to the cytoplasm and their degradation by the proteasome. Belongs to the AUP1 family. Detected in blood platelets and leukocytes (at protein level). Ubiquitous. Highly expressed in placenta, liver, kidney, skeletal muscle, heart and brain. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Endoplasmic reticulum; Membrane protein, integral; Transferase
Chromosomal Location of Human Ortholog: 6 C3|6 35.94 cM
Cellular Component:  endoplasmic reticulum; Hrd1p ubiquitin ligase ERAD-L complex; integral component of endoplasmic reticulum membrane; integral component of membrane; membrane
Molecular Function:  ubiquitin binding; ubiquitin-protein transferase activator activity
Biological Process:  retrograde protein transport, ER to cytosol; ubiquitin-dependent ERAD pathway
Reference #:  P70295 (UniProtKB)
Alt. Names/Synonyms: AA589454; ancient ubiquitous protein; Ancient ubiquitous protein 1; Aup1
Gene Symbols: Aup1
Molecular weight: 46,121 Da
Basal Isoelectric point: 8.71  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene