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AUP1
May play a role in the translocation of terminally misfolded proteins from the endoplasmic reticulum lumen to the cytoplasm and their degradation by the proteasome. Belongs to the AUP1 family. Detected in blood platelets and leukocytes (at protein level). Ubiquitous. Highly expressed in placenta, liver, kidney, skeletal muscle, heart and brain. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Endoplasmic reticulum; Membrane protein, integral; Transferase |
| Chromosomal Location of Human Ortholog: 6 C3|6 35.94 cM |
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Cellular Component:
endoplasmic reticulum; Hrd1p ubiquitin ligase ERAD-L complex; integral component of endoplasmic reticulum membrane; integral component of membrane; membrane
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Molecular Function:
ubiquitin binding; ubiquitin-protein transferase activator activity
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Biological Process:
retrograde protein transport, ER to cytosol; ubiquitin-dependent ERAD pathway
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Reference #:
P70295
(UniProtKB)
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Alt. Names/Synonyms: AA589454; ancient ubiquitous protein; Ancient ubiquitous protein 1; Aup1
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Gene Symbols: Aup1
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Molecular weight:
46,121 Da
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Basal Isoelectric point:
8.71
Predict pI for various phosphorylation states
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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