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ARHGEF11
May play a role in the regulation of RhoA GTPase by guanine nucleotide-binding alpha-12 (GNA12) and alpha-13 (GNA13). Acts as guanine nucleotide exchange factor (GEF) for RhoA GTPase and may act as GTPase-activating protein (GAP) for GNA12 and GNA13. Involved in neurotrophin-induced neurite outgrowth. Ubiquitously expressed. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: GEF; GEF, Rac/Rho; Motility/polarity/chemotaxis |
| Chromosomal Location of mouse Ortholog: 3|3 F1 |
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Cellular Component:
cytoplasm; nucleoplasm; plasma membrane
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Molecular Function:
G protein-coupled receptor binding; guanyl-nucleotide exchange factor activity; protein binding
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Biological Process:
G protein-coupled receptor signaling pathway; positive regulation of DNA-templated transcription; Rho protein signal transduction
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Reference #:
Q68FM7
(UniProtKB)
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Alt. Names/Synonyms: Arhgef11; B930073M02; E130307F09; KIAA0380; MGC90827; mKIAA0380; PDZ-Rho; PDZ-RhoGEF; Prg; Rho guanine nucleotide exchange factor (GEF) 11; rho guanine nucleotide exchange factor 11; RhoGEF
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Gene Symbols: Arhgef11
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Molecular weight:
171,803 Da
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Basal Isoelectric point:
5.39
Predict pI for various phosphorylation states
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CST Pathways:
Actin Dynamics
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Microtubule Dynamics
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