ARHGEF11 May play a role in the regulation of RhoA GTPase by guanine nucleotide-binding alpha-12 (GNA12) and alpha-13 (GNA13). Acts as guanine nucleotide exchange factor (GEF) for RhoA GTPase and may act as GTPase-activating protein (GAP) for GNA12 and GNA13. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: GEF; GEF, Rac/Rho; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 3|3 F1
Cellular Component:  cytoplasm
Molecular Function:  G protein-coupled receptor binding; protein binding
Biological Process:  G protein-coupled receptor signaling pathway; positive regulation of transcription, DNA-templated; Rho protein signal transduction
Reference #:  Q68FM7 (UniProtKB)
Alt. Names/Synonyms: Arhgef11; B930073M02; E130307F09; KIAA0380; MGC90827; mKIAA0380; Rho guanine nucleotide exchange factor (GEF) 11
Gene Symbols: Arhgef11
Molecular weight: 171,803 Da
Basal Isoelectric point: 5.39  Predict pI for various phosphorylation states
CST Pathways:  Actin Dynamics  |  Microtubule Dynamics
Select Structure to View Below

ARHGEF11

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene