ANP32B Multifunctional protein working as a cell cycle progression factor as well as a cell survival factor. Required for the progression from the G1 to the S phase. Anti-apoptotic protein which functions as a caspase-3 inhibitor. Has no phosphatase 2A (PP2A) inhibitor activity. Exhibits histone chaperone properties, stimulating core histones to assemble into a nucleosome. Belongs to the ANP32 family. Expressed in heart, lung, pancreas, prostate and in spleen, thymus and placenta. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Chaperone
Chromosomal Location of Human Ortholog: 4|4 B1
Cellular Component:  nucleus
Molecular Function:  histone binding
Biological Process:  G1/S transition of mitotic cell cycle; inner ear development; negative regulation of apoptotic process; positive regulation of cell proliferation; positive regulation of G1/S transition of mitotic cell cycle; roof of mouth development; vasculature development; ventricular system development
Reference #:  Q9EST5 (UniProtKB)
Alt. Names/Synonyms: 2410015B15Rik; acidic (leucine-rich) nuclear phosphoprotein 32 family, member B; Acidic leucine-rich nuclear phosphoprotein 32 family member B; acidic nuclear phosphoprotein 32 family, member B; acidic protein rich in leucines; AN32B; Anp32b; MGC103080; OTTMUSP00000007314; Pal31; PHAPI2a; proliferation related acidic leucine rich protein PAL31; Proliferation-related acidic leucine-rich protein PAL31; Ssp29
Gene Symbols: Anp32b
Molecular weight: 31,079 Da
Basal Isoelectric point: 3.89  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene