p300 a histone acetyltransferase and transcriptional co-activator that regulates transcription via chromatin remodeling. Acetylates all four core histones in nucleosomes. Related to CPB (CREB-binding protein), and like CPB can stimulate transcription through activation of CREB. Specifically inhibited by the adenovirus oncoprotein E1A. A co-activator of HIF1A (hypoxia-inducible factor 1 alpha), and thus plays a role in the stimulation of hypoxia-induced genes such as VEGF. Mediates cAMP-gene regulation by binding specifically to phosphorylated CREB protein. Methylated at R580 and R604 in the KIX domain by CARM1, which blocks association with CREB, inhibits CREB signaling and activates the apoptotic response. Also methylated at R2142 by CARM1, which impairs interaction with NCoA2. Binds to and may be involved in the transforming capacity of the adenovirus E1A protein. Note: This description may include information from UniProtKB.
Protein type: Acetyltransferase; EC; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription, coactivator/corepressor
Chromosomal Location of Human Ortholog: 22q13.2
Cellular Component:  chromosome; cytosol; histone acetyltransferase complex; nucleoplasm; nucleus; protein-DNA complex; transcription factor complex
Molecular Function:  acetyltransferase activity; activating transcription factor binding; androgen receptor binding; beta-catenin binding; chromatin binding; chromatin DNA binding; damaged DNA binding; DNA binding; DNA-binding transcription activator activity, RNA polymerase II-specific; histone acetyltransferase activity; histone butyryltransferase activity; histone crotonyltransferase activity; lysine N-acetyltransferase activity, acting on acetyl phosphate as donor; NF-kappaB binding; nuclear hormone receptor binding; p53 binding; peptide butyryltransferase activity; peptide-lysine-N-acetyltransferase activity; pre-mRNA intronic binding; protein binding; protein C-terminus binding; protein propionyltransferase activity; RNA polymerase II activating transcription factor binding; RNA polymerase II proximal promoter sequence-specific DNA binding; RNA polymerase II regulatory region sequence-specific DNA binding; RNA polymerase II transcription factor binding; STAT family protein binding; tau protein binding; transcription coactivator activity; transcription factor binding; transferase activity, transferring acyl groups; zinc ion binding
Biological Process:  animal organ morphogenesis; apoptotic process; B cell differentiation; behavioral defense response; beta-catenin-TCF complex assembly; cellular response to UV; circadian rhythm; DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest; face morphogenesis; fat cell differentiation; heart development; histone acetylation; histone H2B acetylation; histone H4 acetylation; internal peptidyl-lysine acetylation; internal protein amino acid acetylation; intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator; learning or memory; lung development; macrophage derived foam cell differentiation; megakaryocyte development; multicellular organism growth; N-terminal peptidyl-lysine acetylation; negative regulation of gluconeogenesis; negative regulation of protein oligomerization; negative regulation of transcription by RNA polymerase II; nervous system development; Notch signaling pathway; peptidyl-lysine acetylation; peptidyl-lysine butyrylation; peptidyl-lysine crotonylation; peptidyl-lysine propionylation; platelet formation; positive regulation by host of viral transcription; positive regulation of DNA-binding transcription factor activity; positive regulation of gene expression, epigenetic; positive regulation of neuron projection development; positive regulation of NIK/NF-kappaB signaling; positive regulation of Notch signaling pathway; positive regulation of protein binding; positive regulation of RNA polymerase II regulatory region sequence-specific DNA binding; positive regulation of transcription by RNA polymerase II; positive regulation of transcription from RNA polymerase II promoter involved in unfolded protein response; positive regulation of transcription of Notch receptor target; positive regulation of transcription, DNA-templated; positive regulation of transforming growth factor beta receptor signaling pathway; positive regulation of type I interferon production; protein acetylation; protein destabilization; protein deubiquitination; protein stabilization; regulation of androgen receptor signaling pathway; regulation of autophagy; regulation of cell cycle; regulation of cellular response to heat; regulation of megakaryocyte differentiation; regulation of signal transduction by p53 class mediator; regulation of transcription from RNA polymerase II promoter in response to hypoxia; regulation of transcription, DNA-templated; regulation of tubulin deacetylation; response to estrogen; response to hypoxia; skeletal muscle tissue development; somitogenesis; stimulatory C-type lectin receptor signaling pathway; swimming; thigmotaxis; transcription-coupled nucleotide-excision repair; viral process
Disease: Colorectal Cancer; Menke-hennekam Syndrome 2; Rubinstein-taybi Syndrome 1; Rubinstein-taybi Syndrome 2
Reference #:  Q09472 (UniProtKB)
Alt. Names/Synonyms: E1A binding protein p300; E1A-associated protein p300; E1A-binding protein, 300kD; EP300; Histone acetyltransferase p300; Histone butyryltransferase p300; Histone crotonyltransferase p300; KAT3B; MKHK2; P300; p300 HAT; Protein 2-hydroxyisobutyryltransferase p300; Protein propionyltransferase p300; RSTS2
Gene Symbols: EP300
Molecular weight: 264,161 Da
Basal Isoelectric point: 8.81  Predict pI for various phosphorylation states
CST Pathways:  Angiogenesis  |  G2/M DNA Damage Checkpoint  |  NF-kB Signaling  |  Protein Acetylation
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  CCLE  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  ENZYME  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  NURSA  |  InnateDB  |  Ensembl Protein