p300 a histone acetyltransferase and transcriptional co-activator that regulates transcription via chromatin remodeling. Acetylates all four core histones in nucleosomes. Related to CPB (CREB-binding protein), and like CPB can stimulate transcription through activation of CREB. Specifically inhibited by the adenovirus oncoprotein E1A. A co-activator of HIF1A (hypoxia-inducible factor 1 alpha), and thus plays a role in the stimulation of hypoxia-induced genes such as VEGF. Mediates cAMP-gene regulation by binding specifically to phosphorylated CREB protein. Methylated at R580 and R604 in the KIX domain by CARM1, which blocks association with CREB, inhibits CREB signaling and activates the apoptotic response. Also methylated at R2142 by CARM1, which impairs interaction with NCoA2. Binds to and may be involved in the transforming capacity of the adenovirus E1A protein. Note: This description may include information from UniProtKB.

Protein type: Acetyltransferase; EC 2.3.1.48; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription, coactivator/corepressor

Chromosomal Location of human Ortholog: 22q13.2

Cellular Component: chromatin; cytoplasm; cytosol; histone acetyltransferase complex; nucleoplasm; nucleus; protein-DNA complex; transcription regulator complex

Molecular Function: acetyltransferase activity; acyltransferase activity; beta-catenin binding; chromatin binding; chromatin DNA binding; damaged DNA binding; DNA binding; DNA-binding transcription factor binding; histone acetyltransferase activity; histone butyryltransferase activity; histone crotonyltransferase activity; histone H2B acetyltransferase activity; histone H3 acetyltransferase activity; histone H3K122 acetyltransferase activity; histone H4 acetyltransferase activity; histone lactyltransferase activity; lysine N-acetyltransferase activity, acting on acetyl phosphate as donor; NF-kappaB binding; nuclear androgen receptor binding; nuclear receptor binding; p53 binding; peptide 2-hydroxyisobutyryltransferase activity; peptide butyryltransferase activity; peptide N-acetyltransferase activity; peptide-lysine-N-acetyltransferase activity; pre-mRNA intronic binding; protein binding; protein propionyltransferase activity; RNA polymerase II-specific DNA-binding transcription factor binding; STAT family protein binding; tau protein binding; transcription coactivator activity; transcription coactivator binding; transcription coregulator binding; zinc ion binding

Biological Process: animal organ morphogenesis; apoptotic process; B cell differentiation; behavioral defense response; cell cycle; cellular response to UV; circadian rhythm; face morphogenesis; fat cell differentiation; heart development; histone acetylation; internal peptidyl-lysine acetylation; internal protein amino acid acetylation; intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator; learning or memory; lung development; macrophage derived foam cell differentiation; megakaryocyte development; multicellular organism growth; N-terminal peptidyl-lysine acetylation; negative regulation of gluconeogenesis; negative regulation of protein-containing complex assembly; negative regulation of transcription by RNA polymerase II; nervous system development; peptidyl-lysine acetylation; peptidyl-lysine butyrylation; peptidyl-lysine crotonylation; peptidyl-lysine propionylation; platelet formation; positive regulation by host of viral transcription; positive regulation of DNA-binding transcription factor activity; positive regulation of DNA-templated transcription; positive regulation of neuron projection development; positive regulation of NF-kappaB transcription factor activity; positive regulation of NIK/NF-kappaB signaling; positive regulation of protein binding; positive regulation of protein import into nucleus; positive regulation of receptor signaling pathway via JAK-STAT; positive regulation of RNA polymerase II regulatory region sequence-specific DNA binding; positive regulation of transcription by RNA polymerase II; positive regulation of transforming growth factor beta receptor signaling pathway; protein acetylation; protein destabilization; protein stabilization; regulation of androgen receptor signaling pathway; regulation of autophagy; regulation of cellular response to heat; regulation of glycolytic process; regulation of mitochondrion organization; regulation of signal transduction by p53 class mediator; regulation of tubulin deacetylation; response to estrogen; response to hypoxia; skeletal muscle tissue development; somitogenesis; stimulatory C-type lectin receptor signaling pathway; swimming; thigmotaxis; transcription by RNA polymerase II; transcription initiation-coupled chromatin remodeling

Disease: Colorectal Cancer; Menke-hennekam Syndrome 2; Rubinstein-taybi Syndrome 1; Rubinstein-taybi Syndrome 2

Reference #: Q09472 (UniProtKB)

Alt. Names/Synonyms: E1A binding protein p300; E1A-associated protein p300; E1A-binding protein, 300kD; EP300; Histone acetyltransferase p300; Histone butyryltransferase p300; Histone crotonyltransferase p300; KAT3B; MKHK2; P300; p300 HAT; Protein 2-hydroxyisobutyryltransferase p300; Protein propionyltransferase p300; RSTS2

Gene Symbols: EP300

Molecular weight: 264,161 Da

Basal Isoelectric point: 8.81 Predict pI for various phosphorylation states

CST Pathways: Angiogenesis | G2/M DNA Damage Checkpoint | NF-kB Signaling | Protein Acetylation

Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology^®

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p300

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