RARB iso2 is a receptor for retinoic acid, a potent mammalian morphogen and teratogen that has profound effects on vertebrate development. RARB is a member of the nuclear receptor superfamily. Controls cell function by directly regulating gene expression. Composed of three domains: a modulating N-terminal domain, a DNA-binding domain and a C-terminal steroid-binding domain. Four splice-variant isoforms have been described. Isoform beta-1 and beta-2 are nuclear and isoform beta-4 cytoplasmic. Note: This description may include information from UniProtKB.
Protein type: Motility/polarity/chemotaxis; Nuclear receptor; Oncoprotein
Chromosomal Location of Human Ortholog: 3p24.2
Cellular Component:  cytoplasm; nucleoplasm; nucleus; RNA polymerase II transcription factor complex
Molecular Function:  DNA binding; DNA binding transcription factor activity; drug binding; ligand-dependent nuclear receptor activity; ligand-dependent nuclear receptor transcription coactivator activity; retinoic acid receptor activity; retinoid X receptor binding; steroid hormone receptor activity; transcription factor activity, direct ligand regulated sequence-specific DNA binding; transcription factor binding; zinc ion binding
Biological Process:  brain development; cell differentiation; cellular response to retinoic acid; embryonic eye morphogenesis; embryonic gut development; embryonic hindlimb morphogenesis; embryonic organ development; epithelial cell differentiation; gland development; glandular epithelial cell development; growth plate cartilage development; heart development; hormone-mediated signaling pathway; liver development; multicellular organism development; multicellular organism growth; negative regulation of apoptosis; negative regulation of cell proliferation; negative regulation of chondrocyte differentiation; negative regulation of transcription from RNA polymerase II promoter; outflow tract septum morphogenesis; positive regulation of apoptosis; positive regulation of cell proliferation; positive regulation of neuron differentiation; positive regulation of transcription from RNA polymerase II promoter; regulation of myelination; response to lipid; response to retinoic acid; retinal pigment epithelium development; retinoic acid receptor signaling pathway; signal transduction; steroid hormone mediated signaling; striatum development; transcription initiation from RNA polymerase II promoter; ureteric bud development; ventricular cardiac muscle cell differentiation
Reference #:  P10826-2 (UniProtKB)
Alt. Names/Synonyms: HAP; HBV-activated protein; hepatitis B virus activated protein; NR1B2; Nuclear receptor subfamily 1 group B member 2; RAR-beta; RAR-epsilon; RARB; Retinoic acid receptor beta; retinoic acid receptor beta 2; retinoic acid receptor beta 4; retinoic acid receptor beta 5; retinoic acid receptor, beta; retinoic acid receptor, beta polypeptide; RRB2
Gene Symbols: RARB
Molecular weight: 50,344 Da
Basal Isoelectric point: 7.45  Predict pI for various phosphorylation states
CST Pathways:  Wnt/ß-Catenin Signaling
Select Structure to View Below

RARB iso2

Protein Structure Not Found.

Cross-references to other databases:  cBioPortal  |  Wikipedia  |  Pfam  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  NURSA  |  Ensembl Protein