RARB Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The RXR/RAR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5. In the absence or presence of hormone ligand, acts mainly as an activator of gene expression due to weak binding to corepressors. The RXRA/RARB heterodimer can act as a repressor on the DR1 element and as an activator on the DR5 element. In concert with RARG, required for skeletal growth, matrix homeostasis and growth plate function. Belongs to the nuclear hormone receptor family. NR1 subfamily. Expressed in aortic endothelial cells (at protein level). 4 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Motility/polarity/chemotaxis; Nuclear receptor; Oncoprotein
Chromosomal Location of human Ortholog: 3p24.2
Cellular Component:  chromatin; cytoplasm; nucleoplasm; nucleus
Molecular Function:  DNA binding; DNA-binding transcription factor activity, RNA polymerase II-specific; nuclear receptor activity; nuclear retinoid X receptor binding; protein-containing complex binding; RNA polymerase II cis-regulatory region sequence-specific DNA binding; sequence-specific double-stranded DNA binding; zinc ion binding
Biological Process:  apoptotic process; cell differentiation; embryonic digestive tract development; embryonic eye morphogenesis; embryonic hindlimb morphogenesis; glandular epithelial cell development; growth plate cartilage development; hormone-mediated signaling pathway; multicellular organism growth; negative regulation of chondrocyte differentiation; negative regulation of stem cell proliferation; negative regulation of transcription by RNA polymerase II; neural precursor cell proliferation; neurogenesis; positive regulation of apoptotic process; positive regulation of transcription by RNA polymerase II; regulation of myelination; retinoic acid receptor signaling pathway; signal transduction; stem cell proliferation; striatum development; ureteric bud development; ventricular cardiac muscle cell differentiation
Disease: Microphthalmia, Syndromic 12
Reference #:  P10826 (UniProtKB)
Alt. Names/Synonyms: HAP; HBV-activated protein; hepatitis B virus activated protein; MCOPS12; NR1B2; Nuclear receptor subfamily 1 group B member 2; RAR-beta; RAR-epsilon; RARB; RARbeta1; Retinoic acid receptor beta; retinoic acid receptor beta 2; retinoic acid receptor beta 4; retinoic acid receptor beta 5; retinoic acid receptor, beta; retinoic acid receptor, beta polypeptide; RRB2
Gene Symbols: RARB
Molecular weight: 50,489 Da
Basal Isoelectric point: 8.04  Predict pI for various phosphorylation states
CST Pathways:  Wnt/ß-Catenin Signaling
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Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  NURSA  |  InnateDB  |  Ensembl Protein