RARB Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The RXR/RAR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5. In the absence or presence of hormone ligand, acts mainly as an activator of gene expression due to weak binding to corepressors. The RXRA/RARB heterodimer can act as a repressor on the DR1 element and as an activator on the DR5 element. In concert with RARG, required for skeletal growth, matrix homeostasis and growth plate function. Belongs to the nuclear hormone receptor family. NR1 subfamily. Expressed in aortic endothelial cells (at protein level). 4 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Motility/polarity/chemotaxis; Nuclear receptor; Oncoprotein
Chromosomal Location of Human Ortholog: 3p24.2
Cellular Component:  cytoplasm; nucleoplasm; nucleus
Molecular Function:  DNA binding; DNA-binding transcription factor activity, RNA polymerase II-specific; drug binding; nuclear receptor activity; protein-containing complex binding; retinoid X receptor binding; steroid hormone receptor activity; zinc ion binding
Biological Process:  embryonic digestive tract development; embryonic eye morphogenesis; embryonic hindlimb morphogenesis; glandular epithelial cell development; growth plate cartilage development; multicellular organism growth; negative regulation of apoptotic process; negative regulation of cell proliferation; negative regulation of chondrocyte differentiation; outflow tract septum morphogenesis; positive regulation of apoptotic process; positive regulation of neuron differentiation; regulation of myelination; signal transduction; steroid hormone mediated signaling pathway; striatum development; transcription initiation from RNA polymerase II promoter; ureteric bud development; ventricular cardiac muscle cell differentiation
Disease: Microphthalmia, Syndromic 12
Reference #:  P10826 (UniProtKB)
Alt. Names/Synonyms: HAP; HBV-activated protein; hepatitis B virus activated protein; MCOPS12; NR1B2; Nuclear receptor subfamily 1 group B member 2; RAR-beta; RAR-epsilon; RARB; RARbeta1; Retinoic acid receptor beta; retinoic acid receptor beta 2; retinoic acid receptor beta 4; retinoic acid receptor beta 5; retinoic acid receptor, beta; retinoic acid receptor, beta polypeptide; RRB2
Gene Symbols: RARB
Molecular weight: 50,489 Da
Basal Isoelectric point: 8.04  Predict pI for various phosphorylation states
CST Pathways:  Wnt/ß-Catenin Signaling
Select Structure to View Below

RARB

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  NURSA  |  InnateDB