Merlin Probable regulator of the Hippo/SWH (Sav/Wts/Hpo) signaling pathway, a signaling pathway that plays a pivotal role in tumor suppression by restricting proliferation and promoting apoptosis. Along with WWC1 can synergistically induce the phosphorylation of LATS1 and LATS2 and can probably function in the regulation of the Hippo/SWH (Sav/Wts/Hpo) signaling pathway. May act as a membrane stabilizing protein. May inhibit PI3 kinase by binding to AGAP2 and impairing its stimulating activity. Suppresses cell proliferation and tumorigenesis by inhibiting the CUL4A-RBX1-DDB1-VprBP/DCAF1 E3 ubiquitin-protein ligase complex. Widely expressed. Isoform 1 and isoform 3 are predominant. Isoform 4, isoform 5 and isoform 6 are expressed moderately. Isoform 8 is found at low frequency. Isoform 7, isoform 9 and isoform 10 are not expressed in adult tissues, with the exception of adult retina expressing isoform 10. Isoform 9 is faintly expressed in fetal brain, heart, lung, skeletal muscle and spleen. Fetal thymus expresses isoforms 1, 7, 9 and 10 at similar levels. 10 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Cytoskeletal; Motility/polarity/chemotaxis; Tumor suppressor
Chromosomal Location of Human Ortholog: 22q12.2
Cellular Component:  adherens junction; apical part of cell; cell body; cleavage furrow; cortical actin cytoskeleton; cytoplasm; cytoskeleton; cytosol; early endosome; filopodium membrane; lamellipodium; neuron projection; nucleolus; nucleus; perinuclear region of cytoplasm; plasma membrane; ruffle membrane
Molecular Function:  actin binding; protein binding
Biological Process:  actin cytoskeleton organization; cell-cell junction organization; ectoderm development; hippocampus development; lens fiber cell differentiation; mesoderm formation; negative regulation of cell migration; negative regulation of cell proliferation; negative regulation of cell-cell adhesion; negative regulation of cell-matrix adhesion; negative regulation of JAK-STAT cascade; negative regulation of MAPK cascade; negative regulation of protein kinase activity; negative regulation of tyrosine phosphorylation of STAT protein; odontogenesis of dentin-containing tooth; positive regulation of cell differentiation; positive regulation of stress fiber assembly; regulation of apoptotic process; regulation of cell cycle; regulation of gliogenesis; regulation of hippo signaling; regulation of neural precursor cell proliferation; regulation of protein localization to nucleus; regulation of protein stability; regulation of stem cell proliferation; Schwann cell proliferation
Disease: Meningioma, Familial, Susceptibility To; Neurofibromatosis, Type Ii; Schwannomatosis 1
Reference #:  P35240 (UniProtKB)
Alt. Names/Synonyms: ACN; BANF; MERL; Merlin; moesin-ezrin-radixin like; Moesin-ezrin-radixin-like protein; moesin-ezrin-radizin-like protein; neurofibromin 2; neurofibromin 2 (bilateral acoustic neuroma); neurofibromin 2 (merlin); Neurofibromin-2; NF2; SCH; Schwannomerlin; Schwannomin
Gene Symbols: NF2
Molecular weight: 69,690 Da
Basal Isoelectric point: 6.11  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  InnateDB  |  Ensembl Protein