PLCD3 Hydrolyzes the phosphatidylinositol 4,5-bisphosphate (PIP2) to generate 2 second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). DAG mediates the activation of protein kinase C (PKC), while IP3 releases Ca(2+) from intracellular stores. Essential for trophoblast and placental development. May participate in cytokinesis by hydrolyzing PIP2 at the cleavage furrow. Present in corneal epithelial cells (at protein level). Note: This description may include information from UniProtKB.
Protein type: Carbohydrate Metabolism - inositol phosphate; EC; Phospholipase
Chromosomal Location of Human Ortholog: 11 E1|11 66.71 cM
Cellular Component:  cytoplasm; cytosol; membrane
Molecular Function:  hydrolase activity; metal ion binding; phosphatidylinositol phospholipase C activity; phosphoric diester hydrolase activity
Biological Process:  angiogenesis; inositol trisphosphate biosynthetic process; intracellular signal transduction; labyrinthine layer blood vessel development; lipid catabolic process; lipid metabolic process; regulation of cell proliferation; signal transduction
Reference #:  Q8K2J0 (UniProtKB)
Alt. Names/Synonyms: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-3; 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase delta-3; 2610205J15Rik; Kiaa1964; mKIAA1964; OTTMUSP00000003284; Phosphoinositide phospholipase C-delta-3; phospholipase C, delta 3; Phospholipase C-delta-3; PLC-delta-3; Plcd3
Gene Symbols: Plcd3
Molecular weight: 88,607 Da
Basal Isoelectric point: 6.38  Predict pI for various phosphorylation states
CST Pathways:  ErbB/HER Signaling
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene