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PLCD3
Hydrolyzes the phosphatidylinositol 4,5-bisphosphate (PIP2) to generate 2 second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). DAG mediates the activation of protein kinase C (PKC), while IP3 releases Ca(2+) from intracellular stores. Essential for trophoblast and placental development. May participate in cytokinesis by hydrolyzing PIP2 at the cleavage furrow. Present in corneal epithelial cells (at protein level). Note: This description may include information from UniProtKB.
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| Protein type: Carbohydrate Metabolism - inositol phosphate; EC 3.1.4.11; Phospholipase |
| Chromosomal Location of mouse Ortholog: 11 E1|11 66.71 cM |
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Cellular Component:
cytoplasm; membrane; nucleoplasm; plasma membrane
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Molecular Function:
hydrolase activity; metal ion binding; phosphatidylinositol phospholipase C activity; phosphoric diester hydrolase activity
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Biological Process:
angiogenesis; intracellular signal transduction; labyrinthine layer blood vessel development; lipid catabolic process; lipid metabolic process; regulation of cell population proliferation; signal transduction
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Reference #:
Q8K2J0
(UniProtKB)
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Alt. Names/Synonyms: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-3; 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase delta-3; 2610205J15Rik; Kiaa1964; mKIAA1964; OTTMUSP00000003284; Phosphoinositide phospholipase C-delta-3; phospholipase C, delta 3; Phospholipase C-delta-3; PLC-delta-3; Plcd3
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Gene Symbols: Plcd3
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Molecular weight:
88,607 Da
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Basal Isoelectric point:
6.38
Predict pI for various phosphorylation states
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CST Pathways:
ErbB/HER Signaling
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