|
PLCD3
Hydrolyzes the phosphatidylinositol 4,5-bisphosphate (PIP2) to generate 2 second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). DAG mediates the activation of protein kinase C (PKC), while IP3 releases Ca(2+) from intracellular stores. Essential for trophoblast and placental development. May participate in cytokinesis by hydrolyzing PIP2 at the cleavage furrow. Present in corneal epithelial cells (at protein level). Note: This description may include information from UniProtKB.
|
| Protein type: Carbohydrate Metabolism - inositol phosphate; EC 3.1.4.11; Phospholipase |
| Chromosomal Location of human Ortholog: 17q21.31 |
|
Cellular Component:
cleavage furrow; cytoplasm; nucleoplasm; plasma membrane
|
|
Molecular Function:
metal ion binding; phosphatidylinositol phospholipase C activity
|
|
Biological Process:
angiogenesis; intracellular signal transduction; labyrinthine layer blood vessel development; lipid catabolic process; regulation of cell population proliferation
|
|
Reference #:
Q8N3E9
(UniProtKB)
|
|
Alt. Names/Synonyms: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-3; 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase delta-3; KIAA1964; MGC71172; Phosphoinositide phospholipase C-delta-3; phospholipase C delta 3; phospholipase C, delta 3; Phospholipase C-delta-3; PLC delta3; PLC-delta-3; PLCD3
|
|
Gene Symbols: PLCD3
|
|
Molecular weight:
89,258 Da
|
|
Basal Isoelectric point:
6.52
Predict pI for various phosphorylation states
|
|
CST Pathways:
ErbB/HER Signaling
|
