PDGFD Growth factor that plays an essential role in the regulation of embryonic development, cell proliferation, cell migration, survival and chemotaxis. Potent mitogen for cells of mesenchymal origin. Plays an important role in wound healing. Induces macrophage recruitment, increased interstitial pressure, and blood vessel maturation during angiogenesis. Can initiate events that lead to a mesangial proliferative glomerulonephritis, including influx of monocytes and macrophages and production of extracellular matrix. Belongs to the PDGF/VEGF growth factor family. Expressed at high levels in the heart, pancreas, adrenal gland and ovary and at low levels in placenta, liver, kidney, prostate, testis, small intestine, spleen and colon. In the kidney, expressed by the visceral epithelial cells of the glomeruli. A widespread expression is also seen in the medial smooth muscle cells of arteries and arterioles, as well as in smooth muscle cells of vasa rectae in the medullary area. Expressed in the adventitial connective tissue surrounding the suprarenal artery. In chronic obstructive nephropathy, a persistent expression is seen in glomerular visceral epithelial cells and vascular smooth muscle cells, as well as de novo expression by periglomerular interstitial cells and by some neointimal cells of atherosclerotic vessels. Expression in normal prostate is seen preferentially in the mesenchyme of the gland while expression is increased and more profuse in prostate carcinoma. Expressed in many ovarian, lung, renal and brain cancer-derived cell lines. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Oncoprotein; Secreted; Secreted, signal peptide
Chromosomal Location of mouse Ortholog: 9|9 A1
Cellular Component:  extracellular region; extracellular space; membrane
Molecular Function:  growth factor activity; platelet-derived growth factor receptor binding
Biological Process:  cellular process; cellular response to amino acid stimulus; cellular response to transforming growth factor beta stimulus; multicellular organism development; platelet-derived growth factor receptor signaling pathway; positive regulation of cell division; positive regulation of cell migration; positive regulation of cell proliferation; positive regulation of ERK1 and ERK2 cascade; positive regulation of fibroblast proliferation; positive regulation of glomerular mesangial cell proliferation; positive regulation of MAP kinase activity; positive regulation of monocyte extravasation; positive regulation of phosphatidylinositol 3-kinase signaling; positive regulation of protein autophosphorylation; positive regulation of smooth muscle cell chemotaxis; positive regulation of smooth muscle cell proliferation; regulation of peptidyl-tyrosine phosphorylation
Reference #:  Q925I7 (UniProtKB)
Alt. Names/Synonyms: 1110003I09Rik; PDGF-D; Pdgfd; PDGFD latent form; PDGFD receptor-binding form; Platelet-derived growth factor D; Platelet-derived growth factor D, latent form; Platelet-derived growth factor D, receptor-binding form; platelet-derived growth factor, D polypeptide; SCDGF-B; Scdgfb; Spinal cord-derived growth factor B
Gene Symbols: Pdgfd
Molecular weight: 42,809 Da
Basal Isoelectric point: 7.54  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  Reactome  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene