FCHO2 Functions in an early step of clathrin-mediated endocytosis. Has both a membrane binding/bending activity and the ability to recruit proteins essential to the formation of functional clathrin-coated pits. Has a lipid-binding activity with a preference for membranes enriched in phosphatidylserine and phosphoinositides (Pi(4,5) biphosphate) like the plasma membrane. Its membrane-bending activity might be important for the subsequent action of clathrin and adaptors in the formation of clathrin-coated vesicles. Involved in adaptor protein complex AP-2-dependent endocytosis of the transferrin receptor, it also functions in the AP-2-independent endocytosis of the LDL receptor. Belongs to the FCHO family. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Unknown function
Chromosomal Location of Human Ortholog: 13|13 D1
Cellular Component:  AP-2 adaptor complex; clathrin-coated pit; clathrin-coated vesicle; cytoplasm; cytoskeleton; membrane; plasma membrane; presynaptic endocytic zone membrane
Molecular Function:  cytoskeletal protein binding; identical protein binding; microtubule binding; phosphatidylinositol binding; phosphatidylinositol-4,5-bisphosphate binding; phosphatidylserine binding; phospholipid binding; protein binding; tubulin binding
Biological Process:  clathrin coat assembly; clathrin-dependent endocytosis; endocytosis; membrane invagination; plasma membrane tubulation; protein localization to plasma membrane; synaptic vesicle endocytosis
Reference #:  Q3UQN2 (UniProtKB)
Alt. Names/Synonyms: 5832424M12Rik; AA387320; F-BAR domain only protein 2; FCH domain only 2; FCH domain only protein 2; Fcho2
Gene Symbols: Fcho2
Molecular weight: 88,734 Da
Basal Isoelectric point: 6.45  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene