FAM83A Probable proto-oncogene that functions in the epidermal growth factor receptor/EGFR signaling pathway. Activates both RAS/MAPK and PI3K/AKT/TOR signaling cascades downstream of EGFR. Required for the RAS/MAPK signaling cascade activation upon EGFR stimulation, it also activates both signaling cascades independently of EGFR activation. Belongs to the FAM83 family. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Unknown function
Chromosomal Location of Human Ortholog: 8q24.13
Cellular Component:  cytoplasm
Molecular Function:  phosphatidylinositol 3-kinase regulatory subunit binding; protein binding; protein kinase binding
Biological Process:  cell proliferation; epidermal growth factor receptor signaling pathway
Reference #:  Q86UY5 (UniProtKB)
Alt. Names/Synonyms: BJ-TSA-9; FA83A; FAM83A; family with sequence similarity 83, member A; hypothetical protein LOC84985; MGC14128; Protein FAM83A; TSGP; Tumor antigen BJ-TSA-9; Tumor-specific gene expressed in prostate protein
Gene Symbols: FAM83A
Molecular weight: 47,458 Da
Basal Isoelectric point: 9.04  Predict pI for various phosphorylation states
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FAM83A

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein