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FAM83A
Probable proto-oncogene that functions in the epidermal growth factor receptor/EGFR signaling pathway. Activates both RAS/MAPK and PI3K/AKT/TOR signaling cascades downstream of EGFR. Required for the RAS/MAPK signaling cascade activation upon EGFR stimulation, it also activates both signaling cascades independently of EGFR activation. Belongs to the FAM83 family. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Unknown function |
| Chromosomal Location of human Ortholog: 8q24.13 |
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Cellular Component:
cytoplasm
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Molecular Function:
identical protein binding; phosphatidylinositol 3-kinase regulatory subunit binding; protein binding; protein kinase binding
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Biological Process:
cell population proliferation; epidermal growth factor receptor signaling pathway
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Reference #:
Q86UY5
(UniProtKB)
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Alt. Names/Synonyms: BJ-TSA-9; FA83A; FAM83A; family with sequence similarity 83 member A; family with sequence similarity 83, member A; hypothetical protein LOC84985; MGC14128; Protein FAM83A; TSGP; Tumor antigen BJ-TSA-9; Tumor-specific gene expressed in prostate protein
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Gene Symbols: FAM83A
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Molecular weight:
47,458 Da
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Basal Isoelectric point:
9.04
Predict pI for various phosphorylation states
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