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TMTC1
Transfers mannosyl residues to the hydroxyl group of serine or threonine residues. The 4 members of the TMTC family are O-mannosyl-transferases dedicated primarily to the cadherin superfamily, each member seems to have a distinct role in decorating the cadherin domains with O-linked mannose glycans at specific regions. Also acts as O-mannosyl-transferase on other proteins such as PDIA3. Belongs to the TMTC family. 5 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Membrane protein, integral; Membrane protein, multi-pass |
| Chromosomal Location of Human Ortholog: 6|6 G3 |
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Cellular Component:
endoplasmic reticulum; integral component of membrane; membrane
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Molecular Function:
dolichyl-phosphate-mannose-protein mannosyltransferase activity; mannosyltransferase activity; transferase activity
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Biological Process:
protein O-linked mannosylation; RNA processing
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Reference #:
Q3UV71
(UniProtKB)
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Alt. Names/Synonyms: Arg99; ARG99 homolog; BC023818; Tmtc1; transmembrane and tetratricopeptide repeat containing 1; Transmembrane and TPR repeat-containing protein 1
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Gene Symbols: Tmtc1
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Molecular weight:
105,811 Da
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Basal Isoelectric point:
9.17
Predict pI for various phosphorylation states
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