TMTC1 Transfers mannosyl residues to the hydroxyl group of serine or threonine residues. The 4 members of the TMTC family are O-mannosyl-transferases dedicated primarily to the cadherin superfamily, each member seems to have a distinct role in decorating the cadherin domains with O-linked mannose glycans at specific regions. Also acts as O-mannosyl-transferase on other proteins such as PDIA3. Belongs to the TMTC family. 5 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral; Membrane protein, multi-pass
Chromosomal Location of mouse Ortholog: 6|6 G3
Cellular Component:  endoplasmic reticulum; membrane
Molecular Function:  dolichyl-phosphate-mannose-protein mannosyltransferase activity; mannosyltransferase activity; transferase activity
Biological Process:  protein O-linked mannosylation; RNA processing
Reference #:  Q3UV71 (UniProtKB)
Alt. Names/Synonyms: Arg99; ARG99 homolog; BC023818; Protein O-mannosyl-transferase TMTC1; Tmtc1; transmembrane and tetratricopeptide repeat containing 1; Transmembrane and TPR repeat-containing protein 1
Gene Symbols: Tmtc1
Molecular weight: 105,811 Da
Basal Isoelectric point: 9.17  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene