TMTC1 Transfers mannosyl residues to the hydroxyl group of serine or threonine residues. The 4 members of the TMTC family are O-mannosyl-transferases dedicated primarily to the cadherin superfamily, each member seems to have a distinct role in decorating the cadherin domains with O-linked mannose glycans at specific regions. Also acts as O-mannosyl-transferase on other proteins such as PDIA3. Belongs to the TMTC family. 5 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral; Membrane protein, multi-pass
Chromosomal Location of Human Ortholog: 12p11.22
Cellular Component:  endoplasmic reticulum; integral component of membrane
Molecular Function:  dolichyl-phosphate-mannose-protein mannosyltransferase activity; mannosyltransferase activity
Biological Process:  protein O-linked mannosylation; RNA processing
Reference #:  Q8IUR5 (UniProtKB)
Alt. Names/Synonyms: ARG99; FLJ31400; FLJ41625; OLF; Protein O-mannosyl-transferase TMTC1; TMTC1; TMTC1A; transmembrane and tetratricopeptide repeat containing 1; transmembrane and tetratricopeptide repeat containing 1A; Transmembrane and TPR repeat-containing protein 1; transmembrane O-mannosyltransferase targeting cadherins 1
Gene Symbols: TMTC1
Molecular weight: 98,847 Da
Basal Isoelectric point: 9.05  Predict pI for various phosphorylation states
Select Structure to View Below

TMTC1

Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein