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S100A1
Probably acts as a Ca(2+) signal transducer. In response to an increase in intracellular Ca(2+) levels, binds calcium which triggers a conformational change. This conformational change allows interaction of S1001A with specific target proteins, such as TPR-containing proteins, and the modulation of their activity. Belongs to the S-100 family. Highly prevalent in heart. Also found in lesser quantities in skeletal muscle and brain. Note: This description may include information from UniProtKB.
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| Protein type: Calcium-binding; Endoplasmic reticulum |
| Chromosomal Location of human Ortholog: 1q21.3 |
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Cellular Component:
cytoplasm; cytosol; extracellular region; Golgi apparatus; mitochondrion; nucleoplasm; nucleus; protein-containing complex; sarcoplasmic reticulum
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Molecular Function:
ATPase binding; calcium ion binding; calcium-dependent protein binding; identical protein binding; protein binding; protein homodimerization activity; S100 protein binding
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Biological Process:
intracellular signal transduction; positive regulation of nitric-oxide synthase activity; positive regulation of sprouting angiogenesis; regulation of heart contraction
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Reference #:
P23297
(UniProtKB)
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Alt. Names/Synonyms: Protein S100-A1; S-100 protein alpha chain; S-100 protein subunit alpha; S100; S100 alpha; S100 calcium binding protein A1; S100 calcium-binding protein A1; S100 protein; S100 protein, alpha polypeptide; S100-alpha; S100A; S100A1; S10A1
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Gene Symbols: S100A1
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Molecular weight:
10,546 Da
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Basal Isoelectric point:
4.39
Predict pI for various phosphorylation states
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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