S100A1 Probably acts as a Ca(2+) signal transducer. In response to an increase in intracellular Ca(2+) levels, binds calcium which triggers a conformational change. This conformational change allows interaction of S1001A with specific target proteins, such as TPR-containing proteins, and the modulation of their activity. Belongs to the S-100 family. Highly prevalent in heart. Also found in lesser quantities in skeletal muscle and brain. Note: This description may include information from UniProtKB.
Protein type: Calcium-binding; Endoplasmic reticulum
Chromosomal Location of human Ortholog: 1q21.3
Cellular Component:  cytoplasm; cytosol; extracellular region; Golgi apparatus; mitochondrion; nucleoplasm; nucleus; protein-containing complex; sarcoplasmic reticulum
Molecular Function:  ATPase binding; calcium ion binding; calcium-dependent protein binding; identical protein binding; protein binding; protein homodimerization activity; S100 protein binding
Biological Process:  intracellular signal transduction; positive regulation of nitric-oxide synthase activity; positive regulation of sprouting angiogenesis; regulation of heart contraction
Reference #:  P23297 (UniProtKB)
Alt. Names/Synonyms: Protein S100-A1; S-100 protein alpha chain; S-100 protein subunit alpha; S100; S100 alpha; S100 calcium binding protein A1; S100 calcium-binding protein A1; S100 protein; S100 protein, alpha polypeptide; S100-alpha; S100A; S100A1; S10A1
Gene Symbols: S100A1
Molecular weight: 10,546 Da
Basal Isoelectric point: 4.39  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho.ELM  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene