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PGC-1 beta
Plays a role of stimulator of transcription factors and nuclear receptors activities. Activates transcriptional activity of estrogen receptor alpha, nuclear respiratory factor 1 (NRF1) and glucocorticoid receptor in the presence of glucocorticoids. May play a role in constitutive non-adrenergic-mediated mitochondrial biogenesis as suggested by increased basal oxygen consumption and mitochondrial number when overexpressed. May be involved in fat oxidation and non-oxidative glucose metabolism and in the regulation of energy expenditure. Induces the expression of PERM1 in the skeletal muscle in an ESRRA-dependent manner. Ubiquitous with higher expression in heart, brain and skeletal muscle. 6 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Nuclear receptor co-regulator; Transcription, coactivator/corepressor |
| Chromosomal Location of human Ortholog: 5q32 |
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Cellular Component:
cytosol; mediator complex; mitochondrion; nucleoplasm; nucleus
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Molecular Function:
AF-2 domain binding; nuclear estrogen receptor binding; nuclear receptor coactivator activity; RNA binding; transcription coregulator activity; transcription factor binding
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Biological Process:
actin filament organization; bone trabecula formation; cellular response to reactive oxygen species; intracellular estrogen receptor signaling pathway; mitochondrial transcription; negative regulation of DNA-templated transcription; ossification; positive regulation of alkaline phosphatase activity; positive regulation of bone resorption; positive regulation of cold-induced thermogenesis; positive regulation of DNA-binding transcription factor activity; positive regulation of osteoclast differentiation; positive regulation of phosphorylation; positive regulation of transcription by RNA polymerase II; regulation of DNA-templated transcription
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Disease: Obesity
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Reference #:
Q86YN6
(UniProtKB)
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Alt. Names/Synonyms: DKFZp686C1790; ERRL1; FLJ14284; PERC; Peroxisome proliferator-activated receptor gamma coactivator 1-beta; peroxisome proliferator-activated receptor gamma, coactivator 1 beta; PGC-1 beta; PGC-1(beta); PGC-1-beta; PGC-1-related estrogen receptor alpha coactivator; PGC1; PGC1B; PPAR-gamma coactivator 1-beta; PPARG coactivator 1 beta; PPARgamma coactivator 1 beta; PPARGC-1-beta; PPARGC1; PPARGC1B; PRGC2
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Gene Symbols: PPARGC1B
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Molecular weight:
113,222 Da
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Basal Isoelectric point:
4.94
Predict pI for various phosphorylation states
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