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MARCH7
E3 ubiquitin-protein ligase which may specifically enhance the E2 activity of HIP2. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: EC 6.3.2.-; EC 6.3.2.19; Ligase; Ubiquitin conjugating system; Ubiquitin ligase |
| Chromosomal Location of human Ortholog: 2q24.2 |
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Cellular Component:
cytosol; nucleus; plasma membrane
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Molecular Function:
MDM2/MDM4 family protein binding; protein binding; transferase activity; ubiquitin binding; ubiquitin conjugating enzyme binding; zinc ion binding
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Biological Process:
negative regulation of DNA damage response, signal transduction by p53 class mediator; negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator; negative regulation of proteasomal protein catabolic process; negative regulation of protein autoubiquitination; negative regulation of T cell proliferation; positive regulation of cell population proliferation; positive regulation of protein polyubiquitination; protein autoubiquitination; protein monoubiquitination; protein stabilization; regulation of tolerance induction
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Reference #:
Q9H992
(UniProtKB)
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Alt. Names/Synonyms: AXO; AXOT; Axotrophin; DKFZp586F1122; E3 ubiquitin-protein ligase MARCH7; E3 ubiquitin-protein ligase MARCHF7; MARCH-VII; MARCH7; MARCHF7; MARH7; membrane associated ring finger 7; membrane associated ring-CH-type finger 7; membrane-associated ring finger (C3HC4) 7; membrane-associated ring finger (C3HC4) 7, E3 ubiquitin protein ligase; Membrane-associated RING finger protein 7; Membrane-associated RING-CH protein VII; RING finger protein 177; RING-type E3 ubiquitin transferase MARCH7; RING-type E3 ubiquitin transferase MARCHF7; RNF177
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Gene Symbols: MARCHF7
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Molecular weight:
78,051 Da
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Basal Isoelectric point:
6.32
Predict pI for various phosphorylation states
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