HK1 Belongs to the hexokinase family. Isoform 2 is erythrocyte specific. Isoform 3 and isoform 4 are testis-specific. 4 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Carbohydrate Metabolism - amino sugar and nucleotide sugar; Carbohydrate Metabolism - fructose and mannose; Carbohydrate Metabolism - galactose; Carbohydrate Metabolism - glycolysis and gluconeogenesis; Carbohydrate Metabolism - starch and sucrose; EC 2.7.1.1; Kinase, other; Mitochondrial
Chromosomal Location of Human Ortholog: 10 B4|10 32.37 cM
Cellular Component:  caveola; cilium; cytosol; membrane; membrane raft; mitochondrial outer membrane; mitochondrion; protein-containing complex; sperm principal piece
Molecular Function:  ATP binding; catalytic activity; fructokinase activity; glucokinase activity; glucose binding; hexokinase activity; identical protein binding; kinase activity; mannokinase activity; nucleotide binding; peptidoglycan binding; phosphotransferase activity, alcohol group as acceptor; protein binding; protein homodimerization activity; protein kinase activity; protein-containing complex binding; transferase activity
Biological Process:  canonical glycolysis; carbohydrate metabolic process; carbohydrate phosphorylation; cellular glucose homeostasis; establishment of protein localization to mitochondrion; glycolytic process; maintenance of protein location in mitochondrion; metabolic process; negative regulation of apoptotic process; peptidyl-serine phosphorylation; peptidyl-threonine phosphorylation; peptidyl-tyrosine phosphorylation; phosphorylation; positive regulation of cytokine secretion involved in immune response; positive regulation of interleukin-1 beta secretion; protein autophosphorylation; protein phosphorylation; regulation of anion channel activity; response to ischemia
Reference #:  P17710 (UniProtKB)
Alt. Names/Synonyms: BB404130; dea; downeast anemia; hexokinase 1; Hexokinase type I; Hexokinase, tumor isozyme; Hexokinase-1; HK I; Hk-1; Hk1; Hk1-s; HXK1; mHk1-s
Gene Symbols: Hk1
Molecular weight: 108,303 Da
Basal Isoelectric point: 6.37  Predict pI for various phosphorylation states
CST Pathways:  Warburg Effect
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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HK1

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene