HK1 Belongs to the hexokinase family. Isoform 2 is erythrocyte specific. Isoform 3 and isoform 4 are testis-specific. 4 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Carbohydrate Metabolism - amino sugar and nucleotide sugar; Carbohydrate Metabolism - fructose and mannose; Carbohydrate Metabolism - galactose; Carbohydrate Metabolism - glycolysis and gluconeogenesis; Carbohydrate Metabolism - starch and sucrose; EC; Kinase, other; Mitochondrial
Chromosomal Location of human Ortholog: 10q22.1
Cellular Component:  cytosol; membrane raft; mitochondrial outer membrane; mitochondrion
Molecular Function:  ATP binding; fructokinase activity; glucokinase activity; glucosamine kinase activity; glucose binding; hexokinase activity; mannokinase activity; peptidoglycan binding; protein binding
Biological Process:  canonical glycolysis; carbohydrate phosphorylation; cellular glucose homeostasis; establishment of protein localization to mitochondrion; fructose 6-phosphate metabolic process; glucose 6-phosphate metabolic process; glucose metabolic process; glycolytic process; inflammatory response; innate immune response; maintenance of protein location in mitochondrion; mannose metabolic process; positive regulation of cytokine production involved in immune response; positive regulation of interleukin-1 beta production
Disease: Hemolytic Anemia, Nonspherocytic, Due To Hexokinase Deficiency; Neurodevelopmental Disorder With Visual Defects And Brain Anomalies; Neuropathy, Hereditary Motor And Sensory, Russe Type; Retinitis Pigmentosa 79
Reference #:  P19367 (UniProtKB)
Alt. Names/Synonyms: brain form hexokinase; glycolytic enzyme; hexokinase; hexokinase 1; Hexokinase 1 isoform HKI variant; hexokinase IR; hexokinase type I; Hexokinase-1; Hexokinase-A; HK; HK I; HK1; HK1-ta; HK1-tb; HK1-tc; HKD; HKI; HMSNR; HXK1; NEDVIBA; RP79
Gene Symbols: HK1
Molecular weight: 102,486 Da
Basal Isoelectric point: 6.36  Predict pI for various phosphorylation states
CST Pathways:  Warburg Effect
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  ENZYME  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein