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HK1
Belongs to the hexokinase family. Isoform 2 is erythrocyte specific. Isoform 3 and isoform 4 are testis-specific. 4 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Carbohydrate Metabolism - amino sugar and nucleotide sugar; Carbohydrate Metabolism - fructose and mannose; Carbohydrate Metabolism - galactose; Carbohydrate Metabolism - glycolysis and gluconeogenesis; Carbohydrate Metabolism - starch and sucrose; EC 2.7.1.1; Kinase, other; Mitochondrial |
| Chromosomal Location of human Ortholog: 10q22.1 |
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Cellular Component:
cytosol; membrane raft; mitochondrial outer membrane; mitochondrion
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Molecular Function:
ATP binding; fructokinase activity; glucokinase activity; glucosamine kinase activity; glucose binding; hexokinase activity; mannokinase activity; peptidoglycan binding; protein binding
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Biological Process:
canonical glycolysis; carbohydrate phosphorylation; cellular glucose homeostasis; establishment of protein localization to mitochondrion; fructose 6-phosphate metabolic process; glucose 6-phosphate metabolic process; glucose metabolic process; glycolytic process; inflammatory response; innate immune response; maintenance of protein location in mitochondrion; mannose metabolic process; positive regulation of cytokine production involved in immune response; positive regulation of interleukin-1 beta production
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Disease: Hemolytic Anemia, Nonspherocytic, Due To Hexokinase Deficiency; Neurodevelopmental Disorder With Visual Defects And Brain Anomalies; Neuropathy, Hereditary Motor And Sensory, Russe Type; Retinitis Pigmentosa 79
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Reference #:
P19367
(UniProtKB)
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Alt. Names/Synonyms: brain form hexokinase; glycolytic enzyme; hexokinase; hexokinase 1; Hexokinase 1 isoform HKI variant; hexokinase IR; hexokinase type I; Hexokinase-1; Hexokinase-A; HK; HK I; HK1; HK1-ta; HK1-tb; HK1-tc; HKD; HKI; HMSNR; HXK1; NEDVIBA; RP79
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Gene Symbols: HK1
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Molecular weight:
102,486 Da
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Basal Isoelectric point:
6.36
Predict pI for various phosphorylation states
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CST Pathways:
Warburg Effect
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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