ZFP57 Binds to a 5'-TGCCGC-3' consensus sequence and recognizes the methylated CpG within this element. Transcription regulator required to maintain maternal and paternal gene imprinting, a process by which gene expression is restricted in a parent of origin-specific manner by epigenetic modification of genomic DNA and chromatin, including DNA methylation. Acts by controlling DNA methylation during the earliest multicellular stages of development at multiple imprinting control regions. Required for the establishment of maternal methylation imprints at SNRPN locus. Acts as a transcriptional repressor in Schwann cells. Belongs to the krueppel C2H2-type zinc-finger protein family. ZFP57 subfamily. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: C2H2-type zinc finger protein; Transcription factor
Chromosomal Location of Human Ortholog: 6p22.1
Cellular Component: 
Molecular Function:  DNA binding; DNA-binding transcription factor activity, RNA polymerase II-specific; metal ion binding
Biological Process:  DNA methylation involved in embryo development; regulation of gene expression by genetic imprinting; regulation of transcription by RNA polymerase II
Disease: Diabetes Mellitus, Transient Neonatal, 1
Reference #:  Q9NU63 (UniProtKB)
Alt. Names/Synonyms: bA145L22; bA145L22.2; C6orf40; TNDM1; Zfp-57; ZFP57; ZFP57 zinc finger protein; Zinc finger protein 57 homolog; zinc finger protein 57 homolog (mouse); Zinc finger protein 698; ZNF698
Gene Symbols: ZFP57
Molecular weight: 51,919 Da
Basal Isoelectric point: 9.34  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene