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ALDH1A1
Can convert/oxidize retinaldehyde to retinoic acid. Binds free retinal and cellular retinol-binding protein-bound retinal. May have a broader specificity and oxidize other aldehydes in vivo. Belongs to the aldehyde dehydrogenase family. Note: This description may include information from UniProtKB.
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| Protein type: Apoptosis; Cofactor and Vitamin Metabolism - retinol; EC 1.2.1.36; GAP; GAP, Ras; Oxidoreductase |
| Chromosomal Location of mouse Ortholog: 19 B|19 13.91 cM |
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Cellular Component:
axon; cell projection; cytoplasm; cytosol; synapse
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Molecular Function:
1-pyrroline dehydrogenase activity; 3-chloroallyl aldehyde dehydrogenase activity; 3-deoxyglucosone dehydrogenase activity; aldehyde dehydrogenase (NAD+) activity; aminobutyraldehyde dehydrogenase activity; benzaldehyde dehydrogenase (NAD+) activity; glyceraldehyde-3-phosphate dehydrogenase (NAD+) (non-phosphorylating) activity; identical protein binding; NAD binding; oxidoreductase activity; oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor; retinal dehydrogenase activity
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Biological Process:
9-cis-retinoic acid biosynthetic process; 9-cis-retinoic acid metabolic process; apoptotic process; cellular detoxification of aldehyde; embryonic eye morphogenesis; fructosamine catabolic process; fructose catabolic process; gamma-aminobutyric acid biosynthetic process; lipid metabolic process; maintenance of lens transparency; negative regulation of cold-induced thermogenesis; optic cup morphogenesis involved in camera-type eye development; positive regulation of apoptotic process; response to ethanol; response to oxidative stress; response to xenobiotic stimulus; retinoic acid biosynthetic process; retinoic acid metabolic process; retinoid metabolic process; retinol metabolic process
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Reference #:
P24549
(UniProtKB)
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Alt. Names/Synonyms: Ahd; Ahd-; Ahd-2; Ahd2; AL1A1; alcohol dehydrogenase family 1, subfamily A1; alcohol dehydrogenase family 1, subfamily A2; ALD; aldehyde dehydrogenase 1, liver cytosolic (class 1); Aldehyde dehydrogenase 1A1; Aldehyde dehydrogenase family 1 member A1; aldehyde dehydrogenase family 1, subfamily A1; Aldehyde dehydrogenase, cytosolic; ALDH-E1; Aldh1; Aldh1a1; Aldh1a2; ALHDII; E1; OTTMUSP00000023466; Ral; RALDH 1; RalDH1; Retinal dehydrogenase 1
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Gene Symbols: Aldh1a1
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Molecular weight:
54,468 Da
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Basal Isoelectric point:
7.91
Predict pI for various phosphorylation states
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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