RAPGEF4 Guanine nucleotide exchange factor (GEF) for RAP1A, RAP1B and RAP2A small GTPases that is activated by binding cAMP. Seems not to activate RAB3A. Involved in cAMP-dependent, PKA-independent exocytosis through interaction with RIMS2. Predominantly expressed in brain and adrenal gland. Isoform 2 is expressed in liver. Isoform 1 is expressed in liver at very low levels. 5 human isoforms generated by alternative promoter usage or alternative splicing have been reported. Note: This description may include information from UniProtKB.
Protein type: GEF; GEF, Ras
Chromosomal Location of Human Ortholog: 2q31.1
Cellular Component:  cytosol; hippocampal mossy fiber to CA3 synapse; membrane; plasma membrane
Molecular Function:  cAMP binding; guanyl-nucleotide exchange factor activity; protein binding; Ras GTPase binding; Ras guanyl-nucleotide exchange factor activity
Biological Process:  calcium ion regulated exocytosis; cAMP-mediated signaling; G protein-coupled receptor signaling pathway; insulin secretion; regulation of exocytosis; regulation of insulin secretion; regulation of synaptic vesicle cycle; small GTPase mediated signal transduction
Reference #:  Q8WZA2 (UniProtKB)
Alt. Names/Synonyms: cAMP-GEFII; cAMP-regulated guanine nucleotide exchange factor II; CGEF2; EPAC 2; EPAC2; Exchange factor directly activated by cAMP 2; Exchange protein directly activated by cAMP 2; Nbla00496; putative protein product of Nbla00496; Rap guanine nucleotide exchange factor (GEF) 4; Rap guanine nucleotide exchange factor 4; RAP guanine-nucleotide-exchange factor (GEF) 4; RAPGEF4; RPGF4
Gene Symbols: RAPGEF4
Molecular weight: 115,522 Da
Basal Isoelectric point: 6.37  Predict pI for various phosphorylation states
CST Pathways:  Actin Dynamics  |  GPCR Signaling to MAPKs  |  Growth And Differentiation Control by MAPKs
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein