GRB14 Adapter protein which modulates coupling of cell surface receptor kinases with specific signaling pathways. Binds to, and suppresses signals from, the activated insulin receptor (INSR). Potent inhibitor of insulin-stimulated MAPK3 phosphorylation. Plays a critical role regulating PDPK1 membrane translocation in response to insulin stimulation and serves as an adapter protein to recruit PDPK1 to activated insulin receptor, thus promoting PKB/AKT1 phosphorylation and transduction of the insulin signal. Belongs to the GRB7/10/14 family. Note: This description may include information from UniProtKB.
Protein type: Adaptor/scaffold
Chromosomal Location of Human Ortholog: 2q24.3
Cellular Component:  cytoplasm; cytosol; endosome membrane; intracellular membrane-bounded organelle; plasma membrane
Molecular Function:  identical protein binding; protein homodimerization activity; receptor tyrosine kinase binding; SH3/SH2 adaptor activity
Biological Process:  leukocyte migration; negative regulation of insulin receptor signaling pathway; positive regulation of signal transduction; signal transduction
Reference #:  Q14449 (UniProtKB)
Alt. Names/Synonyms: GRB14; GRB14 adapter protein; Growth factor receptor-bound protein 14
Gene Symbols: GRB14
Molecular weight: 60,988 Da
Basal Isoelectric point: 8.56  Predict pI for various phosphorylation states
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Protein Structure Not Found.

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