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EFNB1
Cell surface transmembrane ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binding to Eph receptors residing on adjacent cells leads to contact-dependent bidirectional signaling into neighboring cells. Shows high affinity for the receptor tyrosine kinase EPHB1/ELK. Can also bind EPHB2 and EPHB3. Binds to, and induces collapse of, commissural axons/growth cones in vitro. May play a role in constraining the orientation of longitudinally projecting axons. Belongs to the ephrin family. Widely expressed (PubMed:8070404, PubMed:7973638). Detected in both neuronal and non-neuronal tissues (PubMed:8070404, PubMed:7973638). Seems to have particularly strong expression in retina, sciatic nerve, heart and spinal cord (PubMed:7973638). Note: This description may include information from UniProtKB.
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| Protein type: Ligand, receptor tyrosine kinase; Membrane protein, integral |
| Chromosomal Location of Human Ortholog: Xq13.1 |
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Cellular Component:
cytoplasm; integral component of plasma membrane; membrane raft; nucleus; plasma membrane; synapse
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Molecular Function:
protein binding
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Biological Process:
cell adhesion; cell-cell signaling; embryonic pattern specification; ephrin receptor signaling pathway; neural crest cell migration; positive regulation of T cell proliferation; T cell costimulation
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Disease: Craniofrontonasal Syndrome
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Reference #:
P98172
(UniProtKB)
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Alt. Names/Synonyms: CFND; CFNS; EFB1; EFL-3; EFL3; EFNB1; ELK ligand; ELK-L; EPH-related receptor tyrosine kinase ligand 2; Ephrin B1; Ephrin-B1; Ephrin-B1 C-terminal fragment; Ephrin-B1 CTF; Ephrin-B1 ICD; Ephrin-B1 intracellular domain; EPLG2; LERK-2; LERK2; ligand of eph-related kinase 2; MGC8782
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Gene Symbols: EFNB1
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Molecular weight:
38,007 Da
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Basal Isoelectric point:
9.1
Predict pI for various phosphorylation states
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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