EFNB1
Cell surface transmembrane ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binding to Eph receptors residing on adjacent cells leads to contact-dependent bidirectional signaling into neighboring cells. Shows high affinity for the receptor tyrosine kinase EPHB1/ELK. Can also bind EPHB2 and EPHB3. Binds to, and induces collapse of, commissural axons/growth cones in vitro. May play a role in constraining the orientation of longitudinally projecting axons. Belongs to the ephrin family. Widely expressed (PubMed:8070404, PubMed:7973638). Detected in both neuronal and non-neuronal tissues (PubMed:8070404, PubMed:7973638). Seems to have particularly strong expression in retina, sciatic nerve, heart and spinal cord (PubMed:7973638). Note: This description may include information from UniProtKB.
|
Protein type: Ligand, receptor tyrosine kinase; Membrane protein, integral |
Chromosomal Location of human Ortholog: Xq13.1 |
Cellular Component:
cytoplasm; membrane raft; nucleus; plasma membrane; synapse
|
Molecular Function:
ephrin receptor binding; protein binding
|
Biological Process:
axon guidance; cell adhesion; cell-cell signaling; embryonic pattern specification; ephrin receptor signaling pathway; neural crest cell migration; positive regulation of T cell proliferation; T cell costimulation; T cell proliferation
|
Disease: Craniofrontonasal Syndrome
|
Reference #:
P98172
(UniProtKB)
|
Alt. Names/Synonyms: CFND; CFNS; EFB1; EFL-3; EFL3; EFNB1; ELK ligand; ELK-L; EPH-related receptor tyrosine kinase ligand 2; Ephrin B1; Ephrin-B1; Ephrin-B1 C-terminal fragment; Ephrin-B1 CTF; Ephrin-B1 ICD; Ephrin-B1 intracellular domain; EPLG2; LERK-2; LERK2; ligand of eph-related kinase 2; MGC8782
|
Gene Symbols: EFNB1
|
Molecular weight:
38,007 Da
|
Basal Isoelectric point:
9.1
Predict pI for various phosphorylation states
|
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
|