EFNB1 Cell surface transmembrane ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binding to Eph receptors residing on adjacent cells leads to contact-dependent bidirectional signaling into neighboring cells. Shows high affinity for the receptor tyrosine kinase EPHB1/ELK. Can also bind EPHB2 and EPHB3. Binds to, and induces collapse of, commissural axons/growth cones in vitro. May play a role in constraining the orientation of longitudinally projecting axons. Belongs to the ephrin family. Widely expressed (PubMed:8070404, PubMed:7973638). Detected in both neuronal and non-neuronal tissues (PubMed:8070404, PubMed:7973638). Seems to have particularly strong expression in retina, sciatic nerve, heart and spinal cord (PubMed:7973638). Note: This description may include information from UniProtKB.
Protein type: Ligand, receptor tyrosine kinase; Membrane protein, integral
Chromosomal Location of human Ortholog: Xq13.1
Cellular Component:  cytoplasm; membrane raft; nucleus; plasma membrane; synapse
Molecular Function:  ephrin receptor binding; protein binding
Biological Process:  axon guidance; cell adhesion; cell-cell signaling; embryonic pattern specification; ephrin receptor signaling pathway; neural crest cell migration; positive regulation of T cell proliferation; T cell costimulation; T cell proliferation
Disease: Craniofrontonasal Syndrome
Reference #:  P98172 (UniProtKB)
Alt. Names/Synonyms: CFND; CFNS; EFB1; EFL-3; EFL3; EFNB1; ELK ligand; ELK-L; EPH-related receptor tyrosine kinase ligand 2; Ephrin B1; Ephrin-B1; Ephrin-B1 C-terminal fragment; Ephrin-B1 CTF; Ephrin-B1 ICD; Ephrin-B1 intracellular domain; EPLG2; LERK-2; LERK2; ligand of eph-related kinase 2; MGC8782
Gene Symbols: EFNB1
Molecular weight: 38,007 Da
Basal Isoelectric point: 9.1  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene