ALDH9A1 Converts gamma-trimethylaminobutyraldehyde into gamma-butyrobetaine with high efficiency (in vitro). Can catalyze the irreversible oxidation of a broad range of aldehydes to the corresponding acids in an NAD-dependent reaction, but with low efficiency. Belongs to the aldehyde dehydrogenase family. Detected in brain (at protein level) (PubMed:8645224). High expression in adult liver, skeletal muscle, and kidney. Low levels in heart, pancreas, lung and brain (PubMed:8786138). Expressed in all regions of the brain. Expression levels are variable in the different brain areas, with the highest levels in the spinal cord and the lowest in the occipital pole. 3 alternative splicing and alternative initiation human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Amino Acid Metabolism - arginine and proline; Amino Acid Metabolism - histidine; Amino Acid Metabolism - lysine degradation; Amino Acid Metabolism - tryptophan; Amino Acid Metabolism - valine, leucine and isoleucine degradation; Carbohydrate Metabolism - ascorbate and aldarate; Carbohydrate Metabolism - butanoate; Carbohydrate Metabolism - glycolysis and gluconeogenesis; Carbohydrate Metabolism - propanoate; Carbohydrate Metabolism - pyruvate; EC; EC; Lipid Metabolism - fatty acid; Lipid Metabolism - glycerolipid; Mitochondrial; Other Amino Acids Metabolism - beta-alanine; Oxidoreductase; Secondary Metabolites Metabolism - limonene and pinene degradation
Chromosomal Location of Human Ortholog: 1q24.1
Cellular Component:  cytoplasm; cytosol
Molecular Function:  1-pyrroline dehydrogenase activity; aldehyde dehydrogenase (NAD) activity; aminobutyraldehyde dehydrogenase activity; glyceraldehyde-3-phosphate dehydrogenase (NAD+) (non-phosphorylating) activity
Biological Process:  carnitine biosynthetic process; cellular aldehyde metabolic process; hormone metabolic process; neurotransmitter biosynthetic process; oxidation-reduction process
Reference #:  P49189 (UniProtKB)
Alt. Names/Synonyms: 4-trimethylaminobutyraldehyde dehydrogenase; AL9A1; aldehyde dehydrogenase (NAD+); aldehyde dehydrogenase 9 family, member A1; aldehyde dehydrogenase 9A1; Aldehyde dehydrogenase E3 isozyme; Aldehyde dehydrogenase family 9 member A1; ALDH4; ALDH7; ALDH9; ALDH9A1; E3; Gamma-aminobutyraldehyde dehydrogenase; R-aminobutyraldehyde dehydrogenase; TMABADH
Gene Symbols: ALDH9A1
Molecular weight: 53,802 Da
Basal Isoelectric point: 5.69  Predict pI for various phosphorylation states
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Protein Structure Not Found.

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