RIN2 Ras effector protein. May function as an upstream activator and/or downstream effector for RAB5B in endocytic pathway. May function as a guanine nucleotide exchange (GEF) of RAB5B, required for activating the RAB5 proteins by exchanging bound GDP for free GTP. Belongs to the RIN (Ras interaction/interference) family. Widely expressed. Expressed in heart, kidney, lung placenta. Expressed at low level in skeletal muscle, spleen and peripheral blood. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: GEF; GEF, Rab; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 20p11.23
Cellular Component:  cytosol
Molecular Function:  GTPase activator activity; GTPase regulator activity; Rab guanyl-nucleotide exchange factor activity
Biological Process:  endocytosis; positive regulation of GTPase activity; small GTPase mediated signal transduction
Disease: Macs Syndrome
Reference #:  Q8WYP3 (UniProtKB)
Alt. Names/Synonyms: MACS; RAB5 interacting protein 2; Ras and Rab interactor 2; RAS association (RalGDS/AF-6) domain containing protein JC265; Ras association domain family 4; Ras inhibitor JC265; Ras interaction/interference protein 2; RASSF4; RIN2
Gene Symbols: RIN2
Molecular weight: 100,163 Da
Basal Isoelectric point: 6.15  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene