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RIN2
Ras effector protein. May function as an upstream activator and/or downstream effector for RAB5B in endocytic pathway. May function as a guanine nucleotide exchange (GEF) of RAB5B, required for activating the RAB5 proteins by exchanging bound GDP for free GTP. Belongs to the RIN (Ras interaction/interference) family. Widely expressed. Expressed in heart, kidney, lung placenta. Expressed at low level in skeletal muscle, spleen and peripheral blood. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: GEF; GEF, Rab; Motility/polarity/chemotaxis |
| Chromosomal Location of Human Ortholog: 20p11.23 |
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Cellular Component:
cytosol
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Molecular Function:
GTPase activator activity; GTPase regulator activity; Rab guanyl-nucleotide exchange factor activity
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Biological Process:
endocytosis; positive regulation of GTPase activity; small GTPase mediated signal transduction
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Disease: Macs Syndrome
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Reference #:
Q8WYP3
(UniProtKB)
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Alt. Names/Synonyms: MACS; RAB5 interacting protein 2; Ras and Rab interactor 2; RAS association (RalGDS/AF-6) domain containing protein JC265; Ras association domain family 4; Ras inhibitor JC265; Ras interaction/interference protein 2; RASSF4; RIN2
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Gene Symbols: RIN2
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Molecular weight:
100,163 Da
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Basal Isoelectric point:
6.15
Predict pI for various phosphorylation states
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