KLF5 Transcription factor that binds to GC box promoter elements. Activates the transcription of these genes. Belongs to the krueppel C2H2-type zinc-finger protein family. Expressed only in testis and placenta. 4 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: C2H2-type zinc finger protein; DNA-binding; Transcription factor
Chromosomal Location of Human Ortholog: 14|14 E2.2
Cellular Component:  Golgi apparatus; intracellular membrane-bounded organelle; nucleoplasm; nucleus; transcription factor complex
Molecular Function:  DNA binding; DNA-binding transcription activator activity, RNA polymerase II-specific; DNA-binding transcription factor activity; DNA-binding transcription factor activity, RNA polymerase II-specific; metal ion binding; MRF binding; nucleic acid binding; protein binding; RNA polymerase II proximal promoter sequence-specific DNA binding; sequence-specific DNA binding; transcription factor binding
Biological Process:  angiogenesis; cell-cell signaling via exosome; cellular response to leukemia inhibitory factor; intestinal epithelial cell development; microvillus assembly; myotube differentiation involved in skeletal muscle regeneration; negative regulation of cardiac vascular smooth muscle cell differentiation; negative regulation of transcription by RNA polymerase II; positive regulation of fat cell differentiation; positive regulation of pri-miRNA transcription by RNA polymerase II; positive regulation of transcription by RNA polymerase II; positive regulation of transcription by transcription factor localization; positive regulation of transcription, DNA-templated; regulation of gene expression; regulation of microvillus assembly; regulation of transcription by RNA polymerase II; regulation of transcription, DNA-templated; satellite cell activation involved in skeletal muscle regeneration; skeletal muscle cell differentiation; skeletal muscle satellite cell differentiation; skeletal muscle tissue regeneration
Reference #:  Q9Z0Z7 (UniProtKB)
Alt. Names/Synonyms: 4930520J07Rik; basic transcription element binding protein 2; Basic transcription element-binding protein 2; BTE-binding protein 2; Bteb2; CKLF; Iklf; Intestinal-enriched krueppel-like factor; Klf5; Krueppel-like factor 5; Kruppel-like factor 5; Transcription factor BTEB2
Gene Symbols: Klf5
Molecular weight: 49,754 Da
Basal Isoelectric point: 8.76  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene