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KLF5
Transcription factor that binds to GC box promoter elements. Activates the transcription of these genes. Belongs to the krueppel C2H2-type zinc-finger protein family. Expressed only in testis and placenta. 4 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: C2H2-type zinc finger protein; DNA-binding; Transcription factor |
| Chromosomal Location of mouse Ortholog: 14|14 E2.2 |
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Cellular Component:
Golgi apparatus; intracellular membrane-bounded organelle; nucleoplasm; nucleus; transcription regulator complex
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Molecular Function:
DNA binding; DNA-binding transcription activator activity, RNA polymerase II-specific; DNA-binding transcription factor activity; DNA-binding transcription factor activity, RNA polymerase II-specific; metal ion binding; MRF binding; protein binding; RNA polymerase II cis-regulatory region sequence-specific DNA binding; sequence-specific DNA binding; sequence-specific double-stranded DNA binding
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Biological Process:
angiogenesis; cell-cell signaling via exosome; cellular response to leukemia inhibitory factor; intestinal epithelial cell development; microvillus assembly; myotube differentiation involved in skeletal muscle regeneration; negative regulation of transcription by RNA polymerase II; positive regulation of DNA-templated transcription; positive regulation of fat cell differentiation; positive regulation of miRNA transcription; positive regulation of transcription by RNA polymerase II; positive regulation of transcription by transcription factor localization; regulation of gene expression; regulation of microvillus assembly; regulation of transcription by RNA polymerase II; satellite cell activation involved in skeletal muscle regeneration; skeletal muscle cell differentiation; skeletal muscle satellite cell differentiation; skeletal muscle tissue regeneration
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Reference #:
Q9Z0Z7
(UniProtKB)
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Alt. Names/Synonyms: 4930520J07Rik; basic transcription element binding protein 2; Basic transcription element-binding protein 2; BTE-binding protein 2; Bteb2; CKL; CKLF; Iklf; Intestinal-enriched krueppel-like factor; Klf5; Krueppel-like factor 5; Kruppel-like factor 5; Transcription factor BTEB2
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Gene Symbols: Klf5
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Molecular weight:
49,754 Da
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Basal Isoelectric point:
8.76
Predict pI for various phosphorylation states
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