KLF5 Transcription factor that binds to GC box promoter elements. Activates the transcription of these genes. Belongs to the krueppel C2H2-type zinc-finger protein family. Note: This description may include information from UniProtKB.
Protein type: C2H2-type zinc finger protein; DNA-binding; Transcription factor
Chromosomal Location of Human Ortholog: 13q22.1
Cellular Component:  Golgi apparatus; intracellular membrane-bounded organelle; nucleoplasm; transcription factor complex
Molecular Function:  DNA-binding transcription activator activity, RNA polymerase II-specific; DNA-binding transcription factor activity, RNA polymerase II-specific; metal ion binding; MRF binding; protein binding; RNA polymerase II proximal promoter sequence-specific DNA binding
Biological Process:  angiogenesis; cell-cell signaling via exosome; cellular response to leukemia inhibitory factor; cellular response to organic cyclic compound; cellular response to peptide; intestinal epithelial cell development; microvillus assembly; myotube differentiation involved in skeletal muscle regeneration; negative regulation of transcription by RNA polymerase II; positive regulation of cell proliferation; positive regulation of fat cell differentiation; positive regulation of pri-miRNA transcription by RNA polymerase II; positive regulation of transcription by RNA polymerase II; positive regulation of transcription by transcription factor localization; regulation of microvillus assembly; satellite cell activation involved in skeletal muscle regeneration; skeletal muscle satellite cell differentiation; transcription by RNA polymerase II
Reference #:  Q13887 (UniProtKB)
Alt. Names/Synonyms: basic transcription element binding protein 2; Basic transcription element-binding protein 2; BTE-binding protein 2; BTEB2; CKLF; Colon krueppel-like factor; colon kruppel-like factor; GC box binding protein 2; GC-box-binding protein 2; IKLF; Intestinal-enriched krueppel-like factor; intestinal-enriched kruppel-like factor; KLF5; Krueppel-like factor 5; Kruppel-like factor 5 (intestinal); Transcription factor BTEB2
Gene Symbols: KLF5
Molecular weight: 50,792 Da
Basal Isoelectric point: 8.86  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

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