DUSP11 Possesses RNA 5'-triphosphatase and diphosphatase activities, but displays a poor protein-tyrosine phosphatase activity. In addition, has phosphatase activity with ATP, ADP and O-methylfluorescein phosphate (in vitro). Binds to RNA. May participate in nuclear mRNA metabolism. Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: EC 3.1.3.-; Motility/polarity/chemotaxis; Phosphatase (non-protein); Protein phosphatase, dual-specificity
Chromosomal Location of Human Ortholog: 6|6 C3
Cellular Component:  fibrillar center; intercellular bridge; nuclear speck; nucleus
Molecular Function:  hydrolase activity; nucleotide phosphatase activity, acting on free nucleotides; phosphatase activity; polynucleotide 5'-phosphatase activity; protein tyrosine phosphatase activity; protein tyrosine/serine/threonine phosphatase activity; RNA binding
Biological Process:  dephosphorylation; polynucleotide 5' dephosphorylation; protein dephosphorylation; RNA metabolic process
Reference #:  Q6NXK5 (UniProtKB)
Alt. Names/Synonyms: 2010300F21Rik; AI481497; dual specificity phosphatase 11 (RNA/RNP complex 1-interacting); Dual specificity protein phosphatase 11; DUS11; Dusp11; OTTMUSP00000027818; Phosphatase that interacts with RNA/RNP complex 1; Pir1; RNA/RNP complex-1-interacting phosphatase
Gene Symbols: Dusp11
Molecular weight: 37,851 Da
Basal Isoelectric point: 9.6  Predict pI for various phosphorylation states
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DUSP11

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  BioGPS  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene