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DUSP11
Possesses RNA 5'-triphosphatase and diphosphatase activities, but displays a poor protein-tyrosine phosphatase activity. In addition, has phosphatase activity with ATP, ADP and O-methylfluorescein phosphate (in vitro). Binds to RNA. May participate in nuclear mRNA metabolism. Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: EC 3.1.3.-; Motility/polarity/chemotaxis; Phosphatase (non-protein); Protein phosphatase, dual-specificity |
| Chromosomal Location of human Ortholog: 2p13.1 |
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Cellular Component:
fibrillar center; intercellular bridge; nuclear speck; nucleoplasm; nucleus
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Molecular Function:
phosphatase activity; polynucleotide 5'-phosphatase activity; protein tyrosine phosphatase activity; protein tyrosine/serine/threonine phosphatase activity; RNA binding
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Biological Process:
protein dephosphorylation; RNA processing
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Reference #:
O75319
(UniProtKB)
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Alt. Names/Synonyms: dual specificity phosphatase 11; dual specificity phosphatase 11 (RNA/RNP complex 1-interacting); Dual specificity protein phosphatase 11; DUS11; DUSP11; Phosphatase that interacts with RNA/RNP complex 1; PIR1; RNA/RNP complex 1-interacting; RNA/RNP complex-1-interacting phosphatase; RNA/RNP complex-interacting phosphatase; serine/threonine specific protein phosphatase
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Gene Symbols: DUSP11
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Molecular weight:
38,939 Da
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Basal Isoelectric point:
9.47
Predict pI for various phosphorylation states
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