DUSP11 Possesses RNA 5'-triphosphatase and diphosphatase activities, but displays a poor protein-tyrosine phosphatase activity. In addition, has phosphatase activity with ATP, ADP and O-methylfluorescein phosphate (in vitro). Binds to RNA. May participate in nuclear mRNA metabolism. Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: EC 3.1.3.-; Motility/polarity/chemotaxis; Phosphatase (non-protein); Protein phosphatase, dual-specificity
Chromosomal Location of human Ortholog: 2p13.1
Cellular Component:  fibrillar center; intercellular bridge; nuclear speck; nucleoplasm; nucleus
Molecular Function:  phosphatase activity; polynucleotide 5'-phosphatase activity; protein tyrosine phosphatase activity; protein tyrosine/serine/threonine phosphatase activity; RNA binding
Biological Process:  protein dephosphorylation; RNA processing
Reference #:  O75319 (UniProtKB)
Alt. Names/Synonyms: dual specificity phosphatase 11; dual specificity phosphatase 11 (RNA/RNP complex 1-interacting); Dual specificity protein phosphatase 11; DUS11; DUSP11; Phosphatase that interacts with RNA/RNP complex 1; PIR1; RNA/RNP complex 1-interacting; RNA/RNP complex-1-interacting phosphatase; RNA/RNP complex-interacting phosphatase; serine/threonine specific protein phosphatase
Gene Symbols: DUSP11
Molecular weight: 38,939 Da
Basal Isoelectric point: 9.47  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein