RAB29 Rab GTPase key regulator in vesicle trafficking. Essential for maintaining the integrity of the endosome-trans-Golgi network structure. Together with LRRK2, plays a role in the retrograde trafficking pathway for recycling proteins, such as mannose 6 phosphate receptor (M6PR), between lysosomes and the Golgi apparatus in a retromer-dependent manner. Regulates neuronal process morphology in the intact central nervous system (CNS). May play a role in the formation of typhoid toxin transport intermediates during Salmonella enterica serovar Typhi (S.Typhi) epithelial cell infection. Belongs to the small GTPase superfamily. Rab family. Ubiquitous. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: G protein; G protein, monomeric; G protein, monomeric, Rab
Chromosomal Location of Human Ortholog: 1|1 E4
Cellular Component:  cis-Golgi network; cytoplasm; cytoskeleton; early endosome; Golgi apparatus; intracellular vesicle; melanosome; membrane; mitochondrion; plasma membrane; recycling endosome; symbiont-containing vacuole; trans-Golgi network; vesicle
Molecular Function:  dynein complex binding; GDP binding; GTP binding; GTPase activity; kinesin binding; nucleotide binding; protein binding; Rab GTPase binding
Biological Process:  cell differentiation; cilium assembly; Golgi organization; intracellular protein transport; mitochondrion organization; multi-organism toxin transport; negative regulation of neuron projection development; positive regulation of intracellular protein transport; positive regulation of receptor recycling; positive regulation of T cell receptor signaling pathway; protein localization to ciliary membrane; protein localization to membrane; protein transport; Rab protein signal transduction; regulation of neuron death; regulation of retrograde transport, endosome to Golgi; response to bacterium; retrograde transport, endosome to Golgi; synapse assembly; T cell activation; vesicle-mediated transport; viral RNA genome replication
Reference #:  Q91YQ1 (UniProtKB)
Alt. Names/Synonyms: MGC28972; MGC36539; OTTMUSP00000018925; OTTMUSP00000018926; Rab; Rab-7-like protein 1; Rab29; RAB29, member RAS oncogene family; RAB7, member RAS oncogene family-like 1; RAB7L; Rab7l1; Ras-related protein Rab-7L1
Gene Symbols: Rab29
Molecular weight: 23,089 Da
Basal Isoelectric point: 7.63  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene