RAB29 Rab GTPase key regulator in vesicle trafficking. Essential for maintaining the integrity of the endosome-trans-Golgi network structure. Together with LRRK2, plays a role in the retrograde trafficking pathway for recycling proteins, such as mannose 6 phosphate receptor (M6PR), between lysosomes and the Golgi apparatus in a retromer-dependent manner. Regulates neuronal process morphology in the intact central nervous system (CNS). May play a role in the formation of typhoid toxin transport intermediates during Salmonella enterica serovar Typhi (S.Typhi) epithelial cell infection. Belongs to the small GTPase superfamily. Rab family. Ubiquitous. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: G protein; G protein, monomeric; G protein, monomeric, Rab
Chromosomal Location of Human Ortholog: 1q32.1
Cellular Component:  cis-Golgi network; cytoplasm; cytoskeleton; cytosol; early endosome; Golgi apparatus; intracellular vesicle; mitochondrion; perinuclear region of cytoplasm; plasma membrane; recycling endosome; symbiont-containing vacuole; trans-Golgi network; vacuole
Molecular Function:  dynein complex binding; GDP binding; GTP binding; kinesin binding; protein binding; Rab GTPase binding
Biological Process:  Golgi organization; mitochondrion organization; multi-organism toxin transport; negative regulation of neuron projection development; positive regulation of intracellular protein transport; positive regulation of receptor recycling; positive regulation of T cell receptor signaling pathway; protein localization to ciliary membrane; protein localization to membrane; regulation of neuron death; regulation of retrograde transport, endosome to Golgi; response to bacterium; retrograde transport, endosome to Golgi; synapse assembly; T cell activation; viral RNA genome replication
Reference #:  O14966 (UniProtKB)
Alt. Names/Synonyms: DKFZp686P1051; Rab-7-like protein 1; RAB29; RAB29, member RAS oncogene family; RAB7, member RAS oncogene family-like 1; RAB7L; RAB7L1; Ras-related protein Rab-7L1
Gene Symbols: RAB29
Molecular weight: 23,155 Da
Basal Isoelectric point: 6.73  Predict pI for various phosphorylation states
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Protein Structure Not Found.

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