S100A14 Modulates P53/TP53 protein levels, and thereby plays a role in the regulation of cell survival and apoptosis. Depending on the context, it can promote cell proliferation or apoptosis. Plays a role in the regulation of cell migration by modulating the levels of MMP2, a matrix protease that is under transcriptional control of P53/TP53. Does not bind calcium. Belongs to the S-100 family. Expressed at highest levels in colon and at moderate levels in thymus, kidney, liver, small intestine, and lung. Low expression in heart and no expression is seen in brain, skeletal muscle, spleen, placenta and peripheral blood leukocytes. Note: This description may include information from UniProtKB.
Protein type: Unknown function
Chromosomal Location of human Ortholog: 1q21.3
Cellular Component:  cell junction; cytosol; nuclear body; perinuclear region of cytoplasm; plasma membrane
Molecular Function:  calcium ion binding; chemokine receptor binding; protein binding
Biological Process:  apoptotic process; calcium ion homeostasis; defense response to bacterium; positive regulation of granulocyte chemotaxis; positive regulation of monocyte chemotaxis; response to lipopolysaccharide; toll-like receptor 4 signaling pathway
Reference #:  Q9HCY8 (UniProtKB)
Alt. Names/Synonyms: BCMP84; breast cancer membrane protein 84; Protein S100-A14; S100 calcium binding protein A14; S100 calcium-binding protein A14; S100A14; S100A15; S10AE; S114
Gene Symbols: S100A14
Molecular weight: 11,662 Da
Basal Isoelectric point: 5.16  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene