CDH3
Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. Expressed in some normal epithelial tissues and in some carcinoma cell lines. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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Protein type: Cell adhesion; Membrane protein, integral; Motility/polarity/chemotaxis |
Chromosomal Location of human Ortholog: 16q22.1 |
Cellular Component:
adherens junction; catenin complex; cell junction; cytoplasm; plasma membrane
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Molecular Function:
cadherin binding; calcium ion binding
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Biological Process:
adherens junction organization; calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules; cell adhesion; cell morphogenesis; cell-cell adhesion mediated by cadherin; cell-cell junction assembly; hair cycle process; homophilic cell adhesion via plasma membrane adhesion molecules; keratinization; multicellular organism development; negative regulation of timing of catagen; negative regulation of transforming growth factor beta2 production; positive regulation of canonical Wnt signaling pathway; positive regulation of gene expression; positive regulation of insulin-like growth factor receptor signaling pathway; positive regulation of keratinocyte proliferation; positive regulation of melanin biosynthetic process; positive regulation of melanosome transport; positive regulation of tyrosinase activity; regulation of hair cycle by canonical Wnt signaling pathway; response to xenobiotic stimulus; retina homeostasis; visual perception
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Disease: Ectodermal Dysplasia, Ectrodactyly, And Macular Dystrophy Syndrome; Hypotrichosis, Congenital, With Juvenile Macular Dystrophy
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Reference #:
P22223
(UniProtKB)
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Alt. Names/Synonyms: CADH3; cadherin 3; cadherin 3, type 1, P-cadherin (placental); Cadherin-3; calcium-dependent adhesion protein, placental; CDH3; CDHP; HJMD; P-cadherin; PCAD; Placental cadherin
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Gene Symbols: CDH3
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Molecular weight:
91,418 Da
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Basal Isoelectric point:
4.61
Predict pI for various phosphorylation states
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CST Pathways:
Adherens Junction Dynamics
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Wnt/ß-Catenin Signaling
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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