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Nur77
Orphan nuclear receptor. May act concomitantly with NURR1 in regulating the expression of delayed-early genes during liver regeneration. Binds the NGFI-B response element (NBRE) 5'-AAAAGGTCA-3'. May inhibit NF-kappa-B transactivation of IL2. Participates in energy homeostasis by sequestrating the kinase STK11 in the nucleus, thereby attenuating cytoplasmic AMPK activation. Plays a role in the vascular response to injury. Belongs to the nuclear hormone receptor family. NR4 subfamily. Fetal muscle and adult liver, brain and thyroid. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Apoptosis; DNA-binding; Nuclear receptor |
| Chromosomal Location of mouse Ortholog: 15|15 F1 |
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Cellular Component:
chromatin; cytoplasm; cytosol; mitochondrion; nuclear membrane; nucleoplasm; nucleus; transcription regulator complex
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Molecular Function:
DNA binding; DNA-binding transcription activator activity, RNA polymerase II-specific; DNA-binding transcription factor activity; DNA-binding transcription factor activity, RNA polymerase II-specific; double-stranded DNA binding; identical protein binding; lipopolysaccharide binding; metal ion binding; nuclear glucocorticoid receptor binding; nuclear receptor activity; protein binding; protein heterodimerization activity; RNA polymerase II cis-regulatory region sequence-specific DNA binding; sequence-specific DNA binding; sequence-specific double-stranded DNA binding; zinc ion binding
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Biological Process:
apoptotic process; cell migration involved in sprouting angiogenesis; cellular response to corticotropin-releasing hormone stimulus; cellular response to fibroblast growth factor stimulus; cellular response to organic substance; cellular response to vascular endothelial growth factor stimulus; detection of lipopolysaccharide; endothelial cell chemotaxis; fat cell differentiation; negative regulation of cell cycle; negative regulation of cysteine-type endopeptidase activity involved in apoptotic process; neurotransmitter secretion involved in regulation of skeletal muscle contraction; non-canonical inflammasome complex assembly; positive regulation of apoptotic process; positive regulation of DNA-templated transcription; positive regulation of endothelial cell proliferation; positive regulation of transcription by RNA polymerase II; regulation of DNA-templated transcription; regulation of transcription by RNA polymerase II; regulation of type B pancreatic cell proliferation; response to amphetamine; response to inorganic substance; skeletal muscle cell differentiation; transcription by RNA polymerase II
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Reference #:
P12813
(UniProtKB)
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Alt. Names/Synonyms: GFR; Gfrp; GFRP1; Hbr; Hbr-; Hbr-1; Hbr1; Hmr; hormone receptor; N10; NGFI; NGFI-B; NGFIB; NP10; Nr4a1; Nuclear hormone receptor NUR/77; Nuclear protein N10; Nuclear receptor subfamily 4 group A member 1; nuclear receptor subfamily 4, group A, member 1; Nur; Nur77; NUR77-1; NUR77-2; Orphan nuclear receptor HMR; TIS1; TR3
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Gene Symbols: Nr4a1
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Molecular weight:
64,738 Da
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Basal Isoelectric point:
6.75
Predict pI for various phosphorylation states
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CST Pathways:
Growth And Differentiation Control by MAPKs
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