Nur77 Orphan nuclear receptor. May act concomitantly with NURR1 in regulating the expression of delayed-early genes during liver regeneration. Binds the NGFI-B response element (NBRE) 5'-AAAAGGTCA-3'. May inhibit NF-kappa-B transactivation of IL2. Participates in energy homeostasis by sequestrating the kinase STK11 in the nucleus, thereby attenuating cytoplasmic AMPK activation. Plays a role in the vascular response to injury. Belongs to the nuclear hormone receptor family. NR4 subfamily. Fetal muscle and adult liver, brain and thyroid. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Apoptosis; DNA-binding; Nuclear receptor
Chromosomal Location of Human Ortholog: 15|15 F1
Cellular Component:  cytoplasm; cytosol; nuclear membrane; nucleus; transcription factor complex
Molecular Function:  DNA binding; DNA-binding transcription activator activity, RNA polymerase II-specific; DNA-binding transcription factor activity; glucocorticoid receptor binding; metal ion binding; nuclear receptor activity; protein binding; protein heterodimerization activity; protein homodimerization activity; RNA polymerase II proximal promoter sequence-specific DNA binding; RNA polymerase II regulatory region sequence-specific DNA binding; sequence-specific DNA binding; steroid hormone receptor activity; transcription factor binding; zinc ion binding
Biological Process:  apoptotic process; cell migration involved in sprouting angiogenesis; cellular response to corticotropin-releasing hormone stimulus; cellular response to fibroblast growth factor stimulus; cellular response to organic substance; cellular response to vascular endothelial growth factor stimulus; endothelial cell chemotaxis; fat cell differentiation; negative regulation of cell cycle; negative regulation of cysteine-type endopeptidase activity involved in apoptotic process; positive regulation of apoptotic process; positive regulation of endothelial cell proliferation; positive regulation of transcription by RNA polymerase II; positive regulation of transcription, DNA-templated; regulation of transcription, DNA-templated; regulation of type B pancreatic cell proliferation; response to inorganic substance; skeletal muscle cell differentiation
Reference #:  P12813 (UniProtKB)
Alt. Names/Synonyms: GFR; Gfrp; GFRP1; Hbr; Hbr-; Hbr-1; Hbr1; Hmr; hormone receptor; N10; NGFI; NGFI-B; NGFIB; NP10; Nr4a1; Nuclear hormone receptor NUR/77; Nuclear protein N10; Nuclear receptor subfamily 4 group A member 1; nuclear receptor subfamily 4, group A, member 1; Nur; Nur77; NUR77-1; NUR77-2; Orphan nuclear receptor HMR; TIS1; TR3
Gene Symbols: Nr4a1
Molecular weight: 64,738 Da
Basal Isoelectric point: 6.75  Predict pI for various phosphorylation states
CST Pathways:  Growth And Differentiation Control by MAPKs
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene  |  NURSA