SPTLC1 Serine palmitoyltransferase (SPT). The heterodimer formed with SPTLC2 or SPTLC3 constitutes the catalytic core. The composition of the serine palmitoyltransferase (SPT) complex determines the substrate preference. The SPTLC1-SPTLC2-SPTSSA complex shows a strong preference for C16-CoA substrate, while the SPTLC1-SPTLC3-SPTSSA isozyme uses both C14-CoA and C16-CoA as substrates, with a slight preference for C14-CoA. The SPTLC1-SPTLC2-SPTSSB complex shows a strong preference for C18-CoA substrate, while the SPTLC1-SPTLC3-SPTSSB isozyme displays an ability to use a broader range of acyl-CoAs, without apparent preference. Required for adipocyte cell viability and metabolic homeostasis. Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Widely expressed. Not detected in small intestine. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: EC; Lipid Metabolism - sphingolipid; Membrane protein, integral; Transferase
Chromosomal Location of human Ortholog: 9q22.31
Cellular Component:  endoplasmic reticulum; endoplasmic reticulum membrane; integral component of membrane; serine C-palmitoyltransferase complex; SPOTS complex
Molecular Function:  protein binding; pyridoxal phosphate binding; serine C-palmitoyltransferase activity
Biological Process:  ceramide biosynthetic process; positive regulation of lipophagy; regulation of fat cell apoptotic process; sphinganine biosynthetic process; sphingolipid biosynthetic process; sphingolipid metabolic process; sphingomyelin biosynthetic process; sphingosine biosynthetic process
Disease: Neuropathy, Hereditary Sensory And Autonomic, Type Ia
Reference #:  O15269 (UniProtKB)
Alt. Names/Synonyms: HSAN; HSAN1; HSN1; LBC1; LCB 1; LCB1; Long chain base biosynthesis protein 1; MGC14645; serine C-palmitoyltransferase; Serine palmitoyltransferase 1; serine palmitoyltransferase long chain base subunit 1; serine palmitoyltransferase, long chain base subunit 1; Serine-palmitoyl-CoA transferase 1; SPT 1; SPT1; SPTC1; SPTI; SPTLC1
Gene Symbols: SPTLC1
Molecular weight: 52,744 Da
Basal Isoelectric point: 5.72  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene