K15 Belongs to the intermediate filament family. Expressed in a discontinuous manner in the basal cell layer of adult skin epidermis, but continuously in the basal layer of fetal skin epidermis and nail. Also expressed in the outer root sheath above the hair bulb in hair follicle (at protein level). Expressed homogeneously in all cell layers of the esophagus and exocervix, but detected in the basal cell layer only of oral mucosa, skin and in the basal plus the next two layers of the suprabasal epithelium of the palate. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Cytoskeletal
Chromosomal Location of Human Ortholog: 17q21.2
Cellular Component:  cytosol; intermediate filament
Molecular Function:  protein binding; scaffold protein binding; structural constituent of cytoskeleton
Biological Process:  cornification; cytoskeleton organization; epidermis development; keratinization
Reference #:  P19012 (UniProtKB)
Alt. Names/Synonyms: CK-15; CK15; cytokeratin 15; Cytokeratin-15; K15; K1C15; K1CO; keratin 15; keratin 15, type I; Keratin, type I cytoskeletal 15; Keratin-15; keratin-15, basic; keratin-15, beta; KRT15; KRTB; type I cytoskeletal 15
Gene Symbols: KRT15
Molecular weight: 49,212 Da
Basal Isoelectric point: 4.71  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene