COPS6 Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. Has some glucocorticoid receptor-responsive activity. Stabilizes COP1 through reducing COP1 auto-ubiquitination and decelerating COP1 turnover rate, hence regulates the ubiquitination of COP1 targets. Belongs to the peptidase M67A family. CSN6 subfamily. Widely expressed. Note: This description may include information from UniProtKB.
Protein type: Cell cycle regulation
Chromosomal Location of Human Ortholog: 5|5 G2
Cellular Component:  COP9 signalosome; cytoplasm; nucleoplasm; nucleus
Molecular Function:  protein binding
Biological Process:  protein deneddylation
Reference #:  O88545 (UniProtKB)
Alt. Names/Synonyms: COP9 (constitutive photomorphogenic) homolog, subunit 6; COP9 (constitutive photomorphogenic) homolog, subunit 6 (Arabidopsis thaliana); COP9 (constitutive photomorphogenic), subunit 6; COP9 complex S6; COP9 signalosome complex subunit 6; COP9 signalosome subunit 6; Cops6; Csn6; JAB1-containing signalosome subunit 6; OTTMUSP00000025868; Sgn3; SGN6; Signalosome subunit 6; VIP/; VIP/MOV34
Gene Symbols: Cops6
Molecular weight: 35,880 Da
Basal Isoelectric point: 5.47  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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COPS6

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene