K16 Epidermis-specific type I keratin that plays a key role in skin. Acts as a regulator of innate immunity in response to skin barrier breach: required for some inflammatory checkpoint for the skin barrier maintenance. Belongs to the intermediate filament family. Expressed in the hair follicle, nail bed and in mucosal stratified squamous epithelia and, suprabasally, in oral epithelium and palmoplantar epidermis. Also found in luminal cells of sweat and mammary gland ducts. Note: This description may include information from UniProtKB.
Protein type: Cytoskeletal
Chromosomal Location of Human Ortholog: 17q21.2
Cellular Component:  cytoskeleton; cytosol; intermediate filament
Molecular Function:  protein binding; structural constituent of cytoskeleton
Biological Process:  aging; cornification; cytoskeleton organization; establishment of skin barrier; hair cycle; inflammatory response; innate immune response; intermediate filament cytoskeleton organization; keratinization; keratinocyte differentiation; keratinocyte migration; morphogenesis of an epithelium; negative regulation of cell migration
Disease: Pachyonychia Congenita 1; Palmoplantar Keratoderma, Nonepidermolytic, Focal
Reference #:  P08779 (UniProtKB)
Alt. Names/Synonyms: CK-16; CK16; cytokeratin 16; Cytokeratin-16; FNEPPK; focal non-epidermolytic palmoplantar keratoderma; K16; K1C16; K1CP; keratin 16; keratin 16, type I; Keratin, type I cytoskeletal 16; Keratin-16; KRT16; KRT16A; NEPPK; PC1
Gene Symbols: KRT16
Molecular weight: 51,268 Da
Basal Isoelectric point: 4.98  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene